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Rabbit Anti-MYOG Polyclonal Antibody#abs137750

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Description

Catalog-specification	Delivery time	USD price
abs137750-100ug	1-2 Weeks	301.0
abs137750-50ug	1-2 Weeks	201.0

Overview
catalog	abs137750
Other names	Myof 4 is a Class C basic helix-loop-helix protein (bHLHc3) also known as Myogenic factor 4 or Myogenin. It is encoded by the MYOG gene in humans. Myof 4 plays a crucial role in muscle development and differentiation. It acts as a transcription factor, regulating the expression of genes involved in muscle formation. The protein is commonly referred to as Myf-4 or MYOG_HUMAN. Another name for Myof 4 is Myogenin factor 4. The gene is also known by the symbol MYOG and the identifier OTTHUMP00000039094.
Source	Rabbit
Specificity	The MYOG Antibody is specifically designed to recognize and measure the endogenous levels of total MYOG protein. It is a reliable tool for detecting the presence of MYOG in biological samples. By using this antibody, researchers can accurately analyze and quantify MYOG expression, which is crucial for studying its role in various cellular processes and diseases.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	MYOG
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human MYOG.
MW	25 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography for purification purposes. To obtain highly purified antiserum, this method proved to be effective in isolating the desired peptides from the sample.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of your product, we recommend storing it at a temperature of -20 °C for up to one year. It is important to note that exposing the product to repeated freeze and thaw cycles could potentially compromise its quality, so we advise against doing so. Protect your investment by following these storage guidelines and enjoy your product for longer.
Storage buffer	This product contains Rabbit IgG, dissolved in phosphate buffered saline at a pH of 7.4, with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at a temperature of -20 °C, with a shelf life of 12 months from the date of receipt. Please note that this content has been rephrased to convey the same information as the original text using different wording.
Target
Background	Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity).
Posttranslational modification	Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner. Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles (By similarity).
Celluar localization	Nucleus;
UniPort	P15173