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Rabbit Anti-SLC9A3R1 Polyclonal Antibody#abs137748

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Description

Catalog-specification	Delivery time	USD price
abs137748-100ug	1-2 Weeks	301.0
abs137748-50ug	1-2 Weeks	201.0

Overview
catalog	abs137748
Other names	NHERF1, also known as Na(+)/H(+) exchange regulatory cofactor NHE RF or Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50), is a regulatory cofactor of the sodium/hydrogen exchanger (NHE) and plays an important role in signal transduction and ion transport. NHERF1 is a member of the solute carrier family 9 (SLC9) and is involved in regulating ion transport across cell membranes. It binds to NHE and modulates its activity through intracellular signaling pathways. Additionally, NHERF1 is involved in the regulation of a variety of membrane transporters and receptors, making it an important player in cell signaling and homeostasis. The protein is encoded by the Slc9a3r1 gene and is expressed in various tissues throughout the body. Understanding the function of NHERF1 is essential for the development of new therapies targeted at disorders that involve ion transport dysregulation.
Source	Rabbit
Specificity	The total levels of endogenous SLC9A3R1 can be detected using the SLC9A3R1 Antibody. Let's create an alternative version of the content, maintaining its meaning but presenting it in a distinct manner: The SLC9A3R1 Antibody is capable of detecting the overall expression of endogenous SLC9A3R1 within biological samples.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Sheep;Bovine;Dog;Horse;
Antigen	SLC9A3R1
Application	The dilution ratios for WB, IHC, and ELISA assays are as follows: WB should be diluted at a ratio of 1:1000-3000, IHC at a ratio of 1:200, and ELISA (peptide) at a ratio of 1:20000-1:40000. These dilution ratios are crucial for accurate and reliable results in these experiments. It is important to carefully follow the recommended dilution guidelines to ensure the success of your assays.
Immunogen	A synthesized peptide derived from human SLC9A3R1.
MW	39 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly purified antiserum was obtained through this process.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.
Tissue specificity	Detected in liver, kidney, pancreas, prostate, spleen, small intestine and placenta, in particular in the syncytiotrophoblast.
Posttranslational modification	Phosphorylated on serine residues.
Celluar localization	Cytoskeleton;Extracellular region or secreted;Plasma Membrane;
UniPort	O14745