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Rabbit Anti-JAG1 Polyclonal Antibody#abs137746

Description

Catalog-specification	Delivery time	USD price
abs137746-100ug	1-2 Weeks	301.0
abs137746-50ug	1-2 Weeks	201.0

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Overview
catalog	abs137746
Other names	The following are different names and abbreviations for Jagged 1 - a protein that plays a critical role in embryonic development and cellular communication. It is also associated with Alagille syndrome, a genetic disorder that affects various organs in the body. Some of the aliases for this protein include AGS, AHD, AWS, CD 339, Headturner, and hJ1. Other names are Ser 1, Serrate 1, and Slalom. Jagged 1 is also known as CD339 or CD339 antigen and is encoded by the JAG1 gene. This protein belongs to the Notch signaling pathway, which is essential for embryonic development, tissue homeostasis, and cell differentiation. Jagged 1 interacts with receptors on adjacent cells, leading to cell-to-cell communication and regulation of various biological processes such as proliferation, differentiation, and survival. Mutations in the JAG1 gene have been linked to Alagille syndrome, a rare genetic disorder characterized by liver damage, cardiac defects, skeletal abnormalities, and other health complications. Alagille syndrome affects various organs and systems in the body, and the severity of symptoms can vary widely among individuals. Jagged 1 is a promising target for therapeutic intervention in various diseases, including cancer, immunological disorders, cardiovascular diseases, and neurological disorders. Researchers are exploring different ways to modulate the activity of Jagged 1 or its downstream signaling pathways to achieve therapeutic effects.
Source	Rabbit
Specificity	The JAG1 Antibody is capable of detecting total JAG1 at its endogenous levels. This information can be rearranged to form a similar content as follows: Endogenous levels of total JAG1 can be detected with the JAG1 Antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit
Antigen	JAG1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human JAG1.
MW	134 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20 °C for a period of one year. It is important to note that frequent freezing and thawing should be avoided at all costs in order to maintain the integrity of the product. Therefore, it is recommended to store the product in a stable environment to prevent degradation and loss of efficacy over time.
Storage buffer	The Rabbit IgG is stored in phosphate buffered saline (pH 7.4) containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store it at -20 °C. This product has a stability period of 12 months from the date of receipt.
Target
Background	Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).
Tissue specificity	Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P78504