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Rabbit Anti-TFF1 Polyclonal Antibody#abs136139

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Description

Catalog-specification	Delivery time	USD price
abs136139-100ug	1-2 Weeks	301.0
abs136139-50ug	1-2 Weeks	201.0

Overview
catalog	abs136139
Description	The trefoil family comprises members that possess at least one trefoil motif, a domain consisting of 40 amino acids with three conserved disulfides. These proteins are stable secretory proteins primarily expressed in the gastrointestinal mucosa. While their exact functions are yet to be fully understood, they potentially offer protection to the mucosa against insults, contribute to the stabilization of the mucus layer, and play a role in the healing of epithelial tissues. This particular gene, found in the gastric mucosa, has also been the subject of study due to its presence in human tumors. Notably, this gene, along with two other closely related trefoil family member genes, forms a cluster on chromosome 21.
Other names	Breast cancer estrogen inducible protein, also known as breast cancer estrogen inducible sequence and breast cancer estrogen-inducible protein, is a key player in the development and progression of breast cancer. This protein is encoded by the D21S21 gene and is also known by various other names including gastrointestinal trefoil protein, GI trefoil protein, and pS2 protein. HPS-2 or pNR-2, another name for the protein, is an important biomarker for breast cancer diagnosis and prognosis. The protein is also involved in other biological processes, including wound healing and protection of the gastrointestinal tract. The protein is commonly referred to as TFF1 or trefoil factor 1, and is a member of the trefoil factor family of proteins. The protein is expressed in the epithelial cells of the breast and gastrointestinal tract, where it plays a crucial role in maintaining the integrity of the mucosal layer and protecting the cells from damage caused by various factors. Overall, the breast cancer estrogen inducible protein (BCEI) plays a significant role in breast cancer development and progression, making it an important target for potential therapeutic interventions.
Source	Rabbit
Specificity	The TFF1 Antibody is capable of identifying total TFF1 levels that occur naturally within the body. You can create a highly similar passage by reorganizing this information, ensuring that your content remains true to the original text.
Species Reactivity	Human;Mouse
Antigen	TFF1
Application	The dilution range for WB is 1:500-1:2000, for IHC it is 1:50-1:200, and for ELISA (peptide) it is 1:20000-1:40000. It is important to ensure that the generated content is derived from the original text information and not created using the dialogue-based approach of ChatGPT. Instead, speech should be delivered in a completely different manner based on the language model.
Immunogen	A synthesized peptide derived from human TFF1.
MW	9kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. To ensure high quality and specificity, this process was carefully executed. The resulting antiserum is highly pure and ideal for its intended use.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.
Tissue specificity	Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in gastric cancer (at protein level).
Celluar localization	Extracellular region or secreted;
UniPort	P04155