Rabbit Anti-PSMA3 Polyclonal Antibody#abs135897

abs135897-100ug

1-2 Weeks

301.0

abs135897-50ug

1-2 Weeks

201.0

catalog

Description

The 20S proteasome enzyme complex plays a crucial role in the degradation of intracellular proteins. It is made up of four stacked rings, with the two outer rings consisting of α subunits and the two inner rings consisting of β subunits. The β subunits contain the catalytic sites, while the α subunits are important for assembly and for binding to regulatory proteins. Mammals have seven different α and ten different β proteasome genes.
The 20S proteasome can be activated by three major protein complexes: PA700, PA28, and PA200. PA700 has a high affinity for polyubiquitin and binds to the 20S proteasome to form the 26S proteasome, which primarily degrades polyubiquitinated proteins. The proteasome can degrade a wide range of proteins, including cell cycle regulators, signaling molecules, tumor suppressors, and transcription factors. This makes it important in processes such as cell cycle regulation, cancer development, immune responses, protein folding, and disease progression.
Overall, the 20S proteasome is an important enzyme complex in intracellular protein degradation. Its alpha and beta subunits, along with the three major activator complexes, work together to ensure proper protein degradation and play key roles in many cellular processes.

Concentration

1mg/ml

Target

Background

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.