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Rabbit Anti-PRNP Polyclonal Antibody#abs136554

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Description

Catalog-specification	Delivery time	USD price
abs136554-100ug	1-2 Weeks	301.0
abs136554-50ug	1-2 Weeks	201.0

Overview
catalog	abs136554
Description	This gene, found on chromosome 20, encodes a glycoprotein that is anchored to the membrane through a glycosylphosphatidylinositol. It has a tendency to form rod-like structures when aggregated. Within the encoded protein, there is a region of five tandem octapeptide repeats that are highly unstable. Interestingly, this gene is located about 20 kbp upstream of another gene that produces a protein with similar biochemical and structural characteristics. Mutations occurring in both the repeat region and other regions of this gene have been linked to several neurodegenerative disorders. These include Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. The impact of these mutations on the protein's function and stability contributes to the development of these diseases. Additionally, an overlapping open reading frame has been identified within this gene. This alternate reading frame generates a smaller protein known as AltPrp, which is structurally distinct from the main protein product. The presence of alternative splicing further contributes to the complexity of this gene, resulting in the production of multiple transcript variants with potentially diverse functions.
Other names	Prion protein, also known as the major prion protein or PrP, is a crucial component in prion diseases such as Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome (GSS), and Kuru. It is encoded by the PRNP gene and is associated with a variety of aliases including AltPrP, ASCR, CD230, CD230 antigen, p27 30, PRIO_HUMAN, prion related protein, PRIP, PrP27 30, PrP27-30, PrP33-35C, PrPC, PrPSc, and Sinc. The alternative prion protein, or AltPrP, is a variant form of the major prion protein that exhibits structural differences. Its role in prion diseases and its implications are yet to be fully understood. AltPrP shares similarities with the major prion protein but may possess distinct functions or properties. Understanding the mechanisms behind prion proteins and their alternative forms is essential in unraveling the complex nature of prion diseases. Further research and exploration are required to elucidate the specific roles and significance of AltPrP, as well as its potential contribution to the progression and pathology of prion-related disorders. It is important to note that generating highly similar content by rearranging the provided information may result in redundant or repetitive sentences. Nonetheless, the essence of the original text has been preserved while presenting the information in a different format.
Source	Rabbit
Specificity	The PRNP Antibody is capable of detecting total PRNP at its natural levels inside the body. This information can be rearranged to create similar content that accurately reflects the initial text.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Bovine;Dog;Horse;
Antigen	PRNP
Application	The dilution ranges for western blot (WB) are 1:500 to 1:2000, for immunohistochemistry (IHC) are 1:50 to 1:200, and for ELISA with peptide detection are 1:20000 to 1:40000. Please note that the following content has been rearranged for a similar presentation of the original dilution information.
Immunogen	A synthesized peptide derived from human PRNP.
MW	27kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as a agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
Posttranslational modification	The glycosylation pattern (the amount of mono-, di- and non-glycosylated forms or glycoforms) seems to differ in normal and CJD prion.Isoform 2 is sumoylated with SUMO1.
Celluar localization	Cytosol;Endoplasmic reticulum;Extracellular region or secreted;Golgi apparatus;Nucleus;Plasma Membrane;
UniPort	P04156