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Rabbit Anti-PRKD3 Polyclonal Antibody#abs133053

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Description

Catalog-specification	Delivery time	USD price
abs133053-100ug	1-2 Weeks	301.0
abs133053-50ug	1-2 Weeks	201.0

Overview
catalog	abs133053
Description	The function of this particular protein is to transform brief diacylglycerol (DAG) signals into longer-lasting physiological effects that occur downstream of PKC. Additionally, it is involved in enabling resistance to oxidative stress.
Other names	PRKD3, also known as Protein kinase D3 or nPKC nu, is a serine threonine protein kinase that plays an important role in various cellular processes, including cell signaling and apoptosis. It belongs to the Protein kinase C nu type family and is involved in the regulation of protein synthesis, cell growth, and differentiation. PRKD3 is highly similar to other members of the Protein kinase C family, with several shared domains and conserved protein motifs. It is expressed in a variety of tissues, including the brain, heart, liver, and spleen, and is believed to play a key role in the regulation of cell proliferation. As a serine/threonine protein kinase, PRKD3 is involved in the phosphorylation of numerous cellular substrates, including histones, transcription factors, and cytoskeletal proteins. It is also involved in the regulation of ion channels and the transduction of extracellular signals. Overall, PRKD3 plays a critical role in the regulation of cellular functions and is an important target for therapeutic intervention in several diseases, including cancer, cardiovascular disease, and diabetes. Its versatile functions and involvement in multiple signaling pathways make it an attractive target for further study and drug development.
Source	Rabbit
Specificity	The detection of endogenous levels of total PRKD3 can be achieved using the PRKD3 antibody. It is important to note that this antibody specifically targets and detects the overall expression of PRKD3 in biological samples.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Sheep;Dog;Bovine;
Antigen	PRKD3
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	107 kDa;
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. This process resulted in a highly purified antiserum that is suitable for use in various assays and research applications. The use of peptide affinity chromatography allowed for the specific isolation and purification of the target antiserum, resulting in high yields and purity. Overall, this method is an effective strategy for the production of high-quality antiserum for research purposes.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity).
Tissue specificity	Ubiquitous.
Celluar localization	Cytosol;Nucleus;
UniPort	O94806