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Rabbit Anti-PRKAR1A Polyclonal Antibody#abs135662

Please be advised that the price provided is for your reference only. For detailed pricing information, kindly get in touch with our seller, Vecent. Western blot analysis of extracts of various cell linesusingPRKAR1A antibody. This product is for research use only, not for use in diagnostic...

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Description

Catalog-specification	Delivery time	USD price
abs135662-100ug	1-2 Weeks	301.0
abs135662-50ug	1-2 Weeks	201.0

Please be advised that the price provided is for your reference only. For detailed pricing information, kindly get in touch with our seller, Vecent.

Overview
catalog	abs135662
Other names	Here are some variations: 1. PRKAR1A, also known as cAMP dependent protein kinase regulatory subunit alpha 1 or PKA RIA, is a regulatory subunit of the cAMP dependent protein kinase type I alpha. It plays a crucial role in transducing signals generated by extracellular stimuli, including hormones and neurotransmitters, into intracellular responses. PRKAR1A is also associated with Carney complex type 1, a rare genetic disorder characterized by multiple endocrine neoplasias and skin pigmentation abnormalities. 2. TSE1, or tissue-specific extinguisher 1, is another name for PRKAR1A, a protein that belongs to the regulatory subunit of cAMP dependent protein kinase type I alpha. This subunit is essential for the assembly and localization of the catalytic subunit of PKA in specific subcellular domains, such as the plasma membrane, the nucleus, or the mitochondria. In addition, mutations in PRKAR1A have been linked to the development of Carney complex type 1, a condition that affects multiple organs and tissues. 3. PKR1, or cAMP-dependent protein kinase type I-alpha regulatory subunit, is a regulatory subunit that forms a complex with the catalytic subunit of PKA to activate its enzymatic activity in response to cAMP. PKR1 is encoded by the PRKAR1A gene and is involved in a variety of cellular processes, such as gene expression, metabolism, and ion channel activity. Aberrant PKA signaling has been implicated in several diseases, including Carney complex type 1, where it leads to abnormal hormone secretion and tumor growth. 4. CAR, or cAMP dependent protein kinase type I alpha regulatory chain, is a protein that acts as a regulatory subunit of PKA. CAR binds to the catalytic subunit of PKA in the presence of cAMP to release its inhibitory effect and activate the kinase activity of PKA. Mutations in the PRKAR1A gene that encodes CAR have been linked to the development of Carney complex type 1, a rare hereditary disorder characterized by the occurrence of benign tumors in multiple organs, such as the heart, the skin, and the endocrine glands. 5. PRKAR1A/RARA fusion gene is a chimeric gene resulting from the fusion of PRKAR1A and RARA genes. This fusion gene has been detected in a subset of lung adenocarcinomas and acute promyelocytic leukemia, where it may act as an oncogenic driver by altering the transcriptional regulation of several genes involved in cell growth and proliferation. However, the clinical significance of this fusion gene remains to be fully understood.
Source	Rabbit
Specificity	The total PRKAR1A levels in the body can be accurately detected using the PRKAR1A Antibody. This antibody is specifically designed to recognize and bind to the endogenous amounts of PRKAR1A protein. Its high specificity ensures reliable results in studying the presence and expression of PRKAR1A. By detecting the total PRKAR1A, researchers can gain valuable insights into its role and function in various biological processes and diseases.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse;
Antigen	PRKAR1A
Application	The dilution ranges for WB, IHC, IF/ICC, and ELISA(peptide) assays are as follows: WB dilutions range from 1:500 to 1:2000, IHC dilutions range from 1:50 to 1:200, IF/ICC dilutions range from 1:100 to 1:500, and ELISA(peptide) dilutions range from 1:20000 to 1:40000. It is important to note that these dilutions are based on the original text information and should be followed to ensure accurate results.
Immunogen	A synthesized peptide derived from human PRKAR1A.
MW	43kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography. The process resulted in highly purified antiserum that can now be utilized for various applications.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
Tissue specificity	Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
Posttranslational modification	The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.
Celluar localization	Cytosol;Plasma Membrane;
UniPort	P10644