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Rabbit Anti-RAP2B Polyclonal Antibody#abs134712

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Description

Catalog-specification	Delivery time	USD price
abs134712-100ug	1-2 Weeks	301.0
abs134712-50ug	1-2 Weeks	201.0

Overview
catalog	abs134712
Other names	The human gene MGC20484 is also known as RAP2B and belongs to the Ras oncogene family. It encodes for the small GTP binding protein Ras-related protein Rap-2b, which plays a role in signal transduction pathways and cell proliferation. RAP2B is highly similar to RAP2A, and both are involved in regulating various cellular processes. The protein structure of RAP2B includes a GTP-binding domain that enables it to bind to and interact with other proteins in the cellular environment. Dysregulation of RAP2B has been implicated in various diseases, including cancer, cardiovascular disease, and neurological disorders. Therefore, understanding the function and regulation of RAP2B is an important area of study for medical researchers and scientists.
Source	Rabbit
Specificity	The total RAP2B levels can be detected by the RAP2B Antibody, which is capable of recognizing the endogenous protein. In order to create a similar content, the information from the original text has been rearranged to convey the same meaning.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Xenopus;Dog
Antigen	RAP2B
Application	WB1：500〜1：1000，IF/ICC1：100〜1：500，ELISA1：20000〜1：40000。，。
Immunogen	A synthesized peptide.
MW	18 KD
Properties
Concentration	1mg/ml
purification	The purification of the antiserum involved the utilization of SulfoLink™ Coupling Resin for peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	It is advised to store the product at -20 °C for a duration of one year while avoiding repeated freeze/thaw cycles.
Storage buffer	The rabbit IgG is suspended in phosphate-buffered saline (pH 7.4) with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20 °C. This product's stability is guaranteed for 12 months from the date of receipt.
Target
Background	Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.
Tissue specificity	Expressed in red blood cells (at protein level).
Posttranslational modification	Palmitoylated. Unlike RAP2A and RAP2C, palmitoylation of RAP2B is not required for association with recycling endosome membranes and activation of TNIK.
Celluar localization	Cytosol;Endosome;Extracellular region or secreted;Plasma Membrane;
UniPort	P61225