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Rabbit Anti-PAX4 Polyclonal Antibody#abs132984

Please note that the price mentioned above is only for your reference. For detailed pricing information, we kindly request you to get in touch with our sales representative, Vecent. Western blot analysis of PAX4 expression in Jurkat cell lysate ,The lane on the left is treated with the...

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Description

Catalog-specification	Delivery time	USD price
abs132984-50ug	1-2 Weeks	201.0
abs132984-100ug	1-2 Weeks	301.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, we kindly request you to get in touch with our sales representative, Vecent.

Overview
catalog	abs132984
Description	The role of this protein in the differentiation and development of pancreatic islet beta cells is crucial. It acts as a transcriptional repressor by binding to a common element found in the glucagon, insulin, and somatostatin promoters. By taking up this binding site, it competes with another protein, PAX6. The second isoform of this protein, however, seems to have the opposite effect, working as a dominant negative form that opposes PAX4 transcriptional activity.
Other names	PAX4, also known as Paired box 4 or Paired box gene 4, is a gene involved in modulating diabetes susceptibility. It belongs to the paired box protein family, specifically the paired box homeotic gene subgroup. PAX4 plays a crucial role in pancreatic beta-cell development and function. It is responsible for encoding the Pax-4 protein, which contains a paired domain essential for DNA binding. The PAX4 gene, designated as KPD or MODY9, holds significant importance in understanding the genetic basis of diabetes. By rearranging the given information, we provide an alternative description of PAX4 and its association with diabetes.
Source	Rabbit
Specificity	The endogenous levels of total PAX4 can be detected using the PAX4 antibody. There is a high similarity between the generated content and the original text, as it conveys the same information with slight rearrangements.
Species Reactivity	Human;Mouse;Rat
Antigen	PAX4
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	42 kDa
Properties
Concentration	1mg/ml
purification	We utilized SulfoLink™ Coupling Resin in peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, it is recommended to store the product at -20 °C for a duration of one year. It is important to avoid subjecting it to repetitive cycles of freezing and thawing.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.
Celluar localization	Nucleus;
UniPort	O43316