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Rabbit Anti-AMPKgamma2 Polyclonal Antibody#abs140360

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Description

Catalog-specification	Delivery time	USD price
abs140360-100ug	1-2 Weeks	301.0
abs140360-50ug	1-2 Weeks	201.0

Overview
catalog	abs140360
Other names	The AMP-activated protein kinase subunit gamma-2, also known as AAKG or AAKG2, is a non-catalytic subunit of the protein kinase AMP-activated gamma 2. It is encoded by the Prkag2 gene and has various aliases such as AMPK gamma2, AMPK subunit gamma 2, and CMH6. This subunit plays a vital role in regulating energy metabolism and is involved in several physiological processes such as glucose uptake and fatty acid oxidation. Additionally, mutations in the Prkag2 gene have been implicated in various diseases including cardiomyopathy and ventricular preexcitation syndrome (WPWS). The H91620p is an alternative name for this subunit, and it is also referred to as the AMPK subunit gamma-2 or AAKG2_HUMAN.
Source	Rabbit
Specificity	The AMPKgamma2 Antibody is capable of detecting the total levels of endogenous AMPKgamma2. To produce similar content, the same message can be conveyed by reordering the wording as follows: The total levels of endogenous AMPKgamma2 can be detected using the AMPKgamma2 Antibody.
Species Reactivity	Human;Mouse;Rat
Antigen	AMPKgamma2
Application	WB 1:1000, ELISA(peptide) 1:20000-1:40000
Immunogen	AMPKgamma2 is a human protein that can be used to synthesize a peptide. This peptide is derived from AMPKgamma2 and is structurally similar to the original protein.
MW	65kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the integrity of the product, it is recommended to store it at a temperature of minus 20 degrees Celsius for a period of one year. It is important to note that the product should not be subjected to repeated freeze and thaw cycles as this can potentially compromise its quality. Hence, it is advisable to handle and store the product in a controlled environment to ensure its efficacy and longevity.
Storage buffer	The provided information is about Rabbit IgG that is stored in a solution containing phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This solution should be stored at a temperature of -20 °C. The stability of the Rabbit IgG is guaranteed for a period of 12 months from the date it is received.
Target
Background	AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
Tissue specificity	Isoform B is ubiquitously expressed except in liver and thymus. The highest level is detected in heart with abundant expression in placenta and testis.
Posttranslational modification	Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.
Celluar localization	Cytosol;Extracellular region or secreted;Nucleus;
UniPort	Q9UGJ0