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Rabbit Anti-OPN4 Polyclonal Antibody#abs135343

Description

Catalog-specification	Delivery time	USD price
abs135343-100ug	1-2 Weeks	301.0
abs135343-50ug	1-2 Weeks	201.0

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Overview
catalog	abs135343
Other names	OPSIN-4, also known as melanopsin or MOP, is a protein encoded by the MGC142118 gene in humans. It plays a crucial role in regulating the phototransduction process and circadian rhythms in various organisms, including humans. Melanopsin, identified as OPN4, is a photopigment primarily found in retinal ganglion cells. This protein is responsible for detecting light and transmitting signals to the brain's suprachiasmatic nucleus, which helps regulate the timing of our internal body clock. By rearranging the original content, the following information about OPSIN-4 and its functions is presented in a different format.
Source	Rabbit
Specificity	The OPN4 Antibody is specifically designed to detect the total levels of endogenous OPN4.
Species Reactivity	Human
Antigen	OPN4
Application	For Western blotting, the recommended dilution range is 1:500 to 1:1000. For immunofluorescence/immunocytochemistry, the suggested dilution is between 1:100 and 1:500. In ELISA assays using peptide as the antigen, the recommended dilution range is 1:20000 to 1:40000. It is important to note these dilutions may vary depending on the specific experimental conditions and target protein.
Immunogen	A synthesized peptide.
MW	55 KD
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin played a key role in purifying the antiserum through peptide affinity chromatography. The resulting product was of high quality and similarity to the original target molecule.
Clonality	Polyclonal Antibody
Stability & Storage	Make sure to store it at -20 °C for a period of one year without subjecting it to repeated freeze/thaw cycles.
Storage buffer	This product contains Rabbit IgG in a phosphate buffered saline solution with a pH of 7.4. It also contains 150mM of NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at a temperature of -20 °C. It has a shelf life of 12 months from the date of receipt.
Target
Background	A photoreceptor is essential for controlling circadian rhythm, as well as influencing non-image forming responses to light such as the pupillary reflex. It is believed that this photoreceptor might have the ability to convert all-trans retinal, which is covalently attached, back to 11-cis retinal, although this is based on similarities with other known systems.
Tissue specificity	Eye. Expression is restricted within the ganglion and amacrine cell layers of the retina.
Celluar localization	Plasma Membrane;
UniPort	Q9UHM6