Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-PSEN2 Polyclonal Antibody#abs137286

Description

Catalog-specification	Delivery time	USD price
abs137286-100ug	1-2 Weeks	301.0
abs137286-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our seller, Vecent. In order to generate a highly similar content, I will rearrange the original text information. However, I will not follow the dialogue-like manner of content generation used by ChapGPT. Instead, I will deliver this information in a completely different style using a language model.

Overview
catalog	abs137286
Other names	Presenilin 2, also known as PS2, is a protein that has been linked to Alzheimer's disease. It is encoded by the genes AD3L, AD3LP, AD4, AD5, and CMD1V. PS2 is a subunit of the presenilin protein complex, which plays a role in the processing of amyloid precursor protein. Abnormal processing of amyloid precursor protein is believed to contribute to the development of Alzheimer's disease. Other aliases for the PS2 protein include E5-1, OTTHUMP00000035671, OTTHUMP00000035672, OTTHUMP00000228286, OTTHUMP00000228288, Presenilin-2 CTF subunit, PSN2_HUMAN, PSNL2, STM-2, and STM2. Understanding the role and function of PS2 and the presenilin complex may lead to new treatments for Alzheimer's disease.
Source	Rabbit
Specificity	The PSEN2 Antibody is capable of detecting total levels of endogenous PSEN2. This means that it can detect the entire amount of the protein that is naturally present in a sample.
Species Reactivity	Human;Mouse;Rat
Antigen	PSEN2
Application	The recommended dilution for Western blotting is between 1:1000 to 1:3000. For immunohistochemistry, the suggested dilution is 1:200. As for ELISA using a peptide, the optimal dilution range is 1:20000 to 1:40000.
Immunogen	A synthesized peptide derived from human PSEN2.
MW	50kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we purified the antiserum through peptide affinity chromatography. We ensured that the antiserum was highly purified to achieve the best results.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain optimal quality, it is advised to store the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freezing and thawing cycles.
Storage buffer	The storage condition for Rabbit IgG is in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20 °C and remains stable for a period of 12 months starting from the date of receipt.
Target
Background	Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
Tissue specificity	Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
Posttranslational modification	Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments.Phosphorylated on serine residues.
Celluar localization	Cytoskeleton;Endoplasmic reticulum;Golgi apparatus;Lysosome;Mitochondrion;Nucleus;Plasma Membrane;
UniPort	P49810