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Rabbit Anti-ODC1 Polyclonal Antibody#abs136232

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Description

Catalog-specification	Delivery time	USD price
abs136232-100ug	1-2 Weeks	301.0
abs136232-50ug	1-2 Weeks	201.0

Overview
catalog	abs136232
Description	ODC1, also known as Ornithine decarboxylase, is a member of the Orn/Lys/Arg decarboxylase class-II family. Its main function is to catalyze the conversion of ornithine to putrescine, which is the initial and crucial step in polyamine biosynthesis. Regulation of ODC1 occurs at various levels, including transcription, translation, and enzyme degradation. Interestingly, polyamines can actually stimulate the degradation of ODC1, acting as a negative feedback control mechanism (PMID:8486633). Additionally, it has been observed that ODC1 can undergo phosphorylation in vivo (PMID:8798774). This particular antibody is designed to specifically recognize and target ODC1.
Other names	ODC, also known as ornithine decarboxylase, is an enzyme that plays a crucial role in the process of polyamine biosynthesis. It exists in two isoforms, ODC1 and ODC2, which are encoded by the genes DCOR_HUMAN and RNODC, respectively. ODC1 and ODC2 are highly similar in terms of their structure and function, both catalyzing the decarboxylation of ornithine to produce putrescine. This enzymatic reaction is an essential step in the synthesis of polyamines, which are involved in various cellular processes such as cell growth, proliferation, and differentiation. The regulation of ODC activity is critical for maintaining the balance of polyamines, as dysregulation can lead to disorders and diseases, including cancer. Further research on ODC and its isoforms is necessary to fully understand their roles and potential therapeutic targets.
Source	Rabbit
Specificity	The ODC1 Antibody is capable of detecting total ODC1 at the endogenous level. To generate similar content from this original text, rearranging and rephrasing the information, we could say that the ODC1 Antibody has the ability to identify and measure the amount of total ODC1 that naturally occurs in a sample.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Sheep;Dog;Horse;
Antigen	ODC1
Application	Sure, here's a rearranged version of the provided information: The dilution range for Western Blot (WB) is 1:500 to 1:2000. For Immunohistochemistry (IHC), the dilution range is 1:50 to 1:200. And for ELISA using peptides, the dilution range is 1:20000 to 1:40000.
Immunogen	A synthesized peptide derived from human ODC1.
MW	51kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly similar statement can be made by rephrasing the original text while maintaining its core meaning.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Tissue specificity	Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).
Posttranslational modification	S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.
Celluar localization	Cytosol;
UniPort	P11926