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Rabbit Anti-GPC3 Polyclonal Antibody#abs136230

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Description

Catalog-specification	Delivery time	USD price
abs136230-100ug	1-2 Weeks	301.0
abs136230-50ug	1-2 Weeks	201.0

Overview
catalog	abs136230
Description	Heparan sulfate proteoglycans found on the surface of cells consist of a protein core that is linked to a varying number of heparan sulfate chains. The core protein of glypican-related integral membrane proteoglycan family members is anchored to the cytoplasmic membrane through a glycosyl phosphatidylinositol linkage. These proteins may play a role in regulating cell growth and division. The gene that encodes this protein is capable of binding to CD26, inhibiting its dipeptidyl peptidase activity, and inducing apoptosis in particular types of cells. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome or Simpson dysmorphia syndrome. Multiple transcript variants arise as a result of alternative splicing.
Other names	Glypican proteoglycan 3, also known as Glypican-3 [Precursor] or GPC3, is a glycosylated protein encoded by the GPC3 gene in humans. It is also referred to as GTR2 2, GTR2-2, Heparan sulphate proteoglycan, Intestinal protein OCI 5, Intestinal protein OCI-5, MXR7, OCI 5, OCI-5, OCI5, SDYS, Secreted glypican-3, SGB, SGBS, or SGBS1. This highly versatile protein plays vital roles in various cellular processes. By rearranging the given information, we can understand the different aspects of Glypican-3 more comprehensively. It is important to note that the generated content is independent of the original text and might not accurately reflect the original intentions. Discover the incredible Glypican proteoglycan 3, also referred to as GPC3 or Glypican-3 [Precursor]. Encoded by the GPC3 gene, this protein is a glycosylated wonder in the human body. Its other aliases include GTR2 2, GTR2-2, Heparan sulphate proteoglycan, Intestinal protein OCI 5, Intestinal protein OCI-5, MXR7, OCI 5, OCI-5, OCI5, SDYS, Secreted glypican-3, SGB, SGBS, and SGBS1. Delve into the multifaceted nature of Glypican-3 and explore its diverse functions in various cellular processes.
Source	Rabbit
Specificity	The GPC3 Antibody is capable of detecting total levels of endogenous GPC3. This means that it can identify the entire amount of GPC3 present in a sample. To generate similar content based on this information, one could rephrase it as follows: "By using the GPC3 Antibody, it is possible to detect the complete levels of naturally occurring GPC3. This means that the antibody can identify all of the GPC3 within a given sample."
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Bovine;Dog;Horse;
Antigen	GPC3
Application	The recommended dilutions for WB are between 1:500 to 1:2000, for IHC they are between 1:50 to 1:200, and for ELISA using a peptide substrate, they are between 1:20000 to 1:40000. It is important to dilute antibodies appropriately to ensure accurate and sensitive detection of the protein of interest.
Immunogen	A synthesized peptide derived from human GPC3.
MW	66kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.
Tissue specificity	Highly expressed in lung, liver and kidney.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;Golgi apparatus;Lysosome;Plasma Membrane;
UniPort	P51654