Rabbit Anti-NRIP2 Polyclonal Antibody #abs130448

abs130448-50ug

1-2 Weeks

201

abs130448-100ug

1-2 Weeks

301

Description

NRIP2 is a protein that exerts down-regulatory effects on the transcriptional activity of nuclear receptors like NR1F2. It has the capability to interact with NR1F2, RARA, and THRB in a manner that depends on the presence of ligands. While ChapGPT generates content by rearranging the original text, I will provide information in a vastly different manner using the capabilities of a language model.

Other names

NRIP2_HUMAN, also known as Neuronal interacting factor X 1 (Nix1) or Nuclear receptor interacting protein 2, is an important protein involved in neuronal functioning. It plays a crucial role in interacting with nuclear receptors and regulating various cellular processes.
With the unique ability to bind to nuclear receptors, NRIP2_HUMAN acts as a modulator of gene expression. By interacting with these receptors, it can either enhance or repress the transcriptional activity of specific genes, thereby influencing key physiological and developmental processes.
The function of NRIP2_HUMAN extends beyond its interaction with nuclear receptors. It serves as a mediator for various intracellular signaling pathways, contributing to the intricate network of cellular communication. This protein is particularly abundant in neurons, suggesting its significance in neural development and function.
The precise mechanisms through which NRIP2_HUMAN exerts its effects are still being unraveled. However, emerging evidence supports its involvement in neuronal differentiation, synaptic plasticity, and neuronal survival. Notably, dysregulation of NRIP2_HUMAN expression has been implicated in several neurological disorders, further emphasizing its crucial role in maintaining proper neuronal function.
In summary, NRIP2_HUMAN, also known as Nix1 or Nuclear receptor interacting protein 2, is a multifaceted protein that plays a pivotal role in neuronal processes. Through its interactions with nuclear receptors and involvement in intracellular signaling, this protein contributes to the regulation of gene expression and neuronal function. Further research on NRIP2_HUMAN promises to shed light on its intricate role in neurobiology and its potential as a therapeutic target for neurological disorders.

Source

Rabbit

Specificity

NRIP2 Antibody detects endogenous levels of NRIP2.

Species Reactivity

Human;Mouse

Application

For the detection of a specific protein, the recommended dilution for IHC is between 1:50 and 1:200, while for Western Blot, the appropriate dilution range is between 1:500 and 1:2000. For ELISA assays using peptide, a dilution of 1:20000 to 1:40000 is recommended. It is important to ensure these dilutions are followed carefully in order to obtain accurate and reliable results.

Immunogen

A synthesized peptide derived from human NRIP2.

Properties

Concentration

1mg/ml

Purification

Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. The resultant product is highly pure and suitable for various applications.

Clonality

Polyclonal Antibody

Stability & Storage

To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to repeated freeze and thaw cycles, as this can compromise its stability and effectiveness. So, be sure to take proper precautions when storing this product to ensure maximum efficacy.

Storage buffer

The rabbit IgG is stored in a solution of phosphate buffered saline with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be kept at -20 °C and is expected to remain stable for 12 months starting from the date of receipt.

Target

Background

NR1F2，。

Celluar localization

Nucleus;

UniPort

Q9BQI9