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Rabbit Anti-NKIRAS2 Polyclonal Antibody#abs132959

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Description

Catalog-specification	Delivery time	USD price
abs132959-100ug	1-2 Weeks	301.0
abs132959-50ug	1-2 Weeks	201.0

Overview
catalog	abs132959
Description	This distinct Ras-like protein plays an atypical role in regulating NF-kappa-B activity with remarkable efficiency. Its primary function is to safeguard NF-kappa-B inhibitor beta (NFKBIB) from degradation induced by various signals, thereby contributing to the heightened resistance of NFKBIB to degradation. A possible mechanism by which this protein exerts its influence is by impeding the phosphorylation of NFKBIB and hindering the nuclear localization of the p65/RELA subunit of NF-kappa-B. While it remains uncertain whether this protein acts as a GTPase, both its GTP- and GDP-bound forms effectively impede NFKBIB phosphorylation. By rearranging the provided information, we gain insights into the distinctive characteristics and regulatory mechanisms of this remarkable protein.
Other names	KBRAS2, also known as I-kappa-B-interacting Ras-like protein 2 or NF-kappa-B inhibitor-interacting Ras-like protein 2, is an important protein involved in various cellular processes. Its role as a Kappa B-Ras protein 2 or NFKB inhibitor interacting Ras-like protein 2 has been well established. Another name for this protein is NKIRAS2 or I kappa B interacting Ras like protein 2. KBRAS2 plays a crucial role in regulating the NF-kappa-B signaling pathway, which controls the transcription of genes involved in inflammation, immunity, cell survival, and proliferation. By interacting with the NF-kappa-B inhibitor, KBRAS2 modulates the activity of NF-kappa-B and regulates the expression of its target genes. Furthermore, KBRAS2 has been implicated in the development and progression of various diseases, including cancer. Its dysregulation can lead to abnormal activation of the NF-kappa-B pathway, resulting in uncontrolled cell growth and survival. The exact mechanisms and functions of KBRAS2 are still being actively studied, and further research is needed to fully understand its role in cellular processes and disease pathogenesis. Nonetheless, its potential as a therapeutic target in various diseases makes KBRAS2 an intriguing molecule for future investigations.
Source	Rabbit
Specificity	The detection of total NKIRAS2 at its endogenous levels can be accomplished using the NKIRAS2 antibody. By rearranging the original content, it is emphasized that the antibody is capable of detecting the desired protein variant present within the biological system.
Species Reactivity	Human;Mouse
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	NKIRAS2
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	22 kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).
Tissue specificity	Widely expressed.
UniPort	Q9NYR9