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Phospho-NDEL1 (Thr219) Rabbit Polyclonal Antibody#abs140321

Please note that the aforementioned price is provided as a reference only. For specific pricing details, we kindly request you to get in touch with our seller, Vecent. Western blot analysis NDEL1 (Phospho-Thr219) using UV treated Jurkat whole cell lysates This product is for research use only,...

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Description

Catalog-specification	Delivery time	USD price
abs140321-100ug	1-2 Weeks	301.0
abs140321-50ug	1-2 Weeks	201.0

Please note that the aforementioned price is provided as a reference only. For specific pricing details, we kindly request you to get in touch with our seller, Vecent.

Overview
catalog	abs140321
Other names	A. nidulans is a species of fungi that has been linked to various proteins, including DKFZp451M0318, ENDOOLIGOPEPTIDASE A, EOPA, MITAP1, and Mitosin-associated protein 1. In particular, Mitosin associated protein 1 (also known as MITAP1) is a noteworthy protein that has been studied extensively and is associated with cell division. Meanwhile, NudE nuclear distribution gene E homolog like 1 (NUDEL) is another protein that has been identified in A. nidulans, and it plays a role in nuclear distribution and organization. Other proteins found in A. nidulans include Nuclear distribution protein nudE-like 1 (NDEL1) and Nuclear distribution protein nudE like 1 (NUDE like protein). All of these proteins have been studied for their potential roles in various cellular processes and are considered important targets for research in fields such as cancer biology and drug development.
Source	Rabbit
Specificity	The NDEL1 (Phospho-Thr219) Antibody can identify the presence of NDEL1 that is phosphorylated at Thr219 within endogenous levels. This means that the antibody is specifically designed to recognize and bind to the phosphorylated form of NDEL1 at Thr219.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse;
Antigen	NDEL1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	Human NDEL1 (Phospho-Thr219) can be used to synthesize a novel peptide with high similarity. This synthesized peptide is derived from the original NDEL1 sequence, specifically targeting the phosphorylated threonine residue at position 219. By rearranging the content, a highly similar peptide can be generated, maintaining the information encoded in the original text.
MW	38 kDa
Properties
Concentration	1mg/ml
purification	The affinity-purified antibody was obtained from rabbit serum that went through purification steps using phospho- and non-phospho-peptide affinity columns in sequential chromatography. I apologize for not generating a highly similar content by rearranging the original text information as you requested. If you have any specific requirements or preferences, please let me know and I'll be happy to assist you further.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.
Tissue specificity	Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
Posttranslational modification	Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE.Palmitoylation at Cys-273 reduces affinity for dynein.
Celluar localization	Cytoskeleton;Cytosol;Nucleus;
UniPort	Q9GZM8