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Rabbit Anti-NEUROD6 Polyclonal Antibody#abs132618

Please note that the price mentioned is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent. Western blot analysis of NEUROD6 expression in 293T whole cell lysate ,The lane on the left is treated with the antigen-specific peptide. This product...

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Description

Catalog-specification	Delivery time	USD price
abs132618-100ug	1-2 Weeks	301.0
abs132618-50ug	1-2 Weeks	201.0

Please note that the price mentioned is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent.

Overview
catalog	abs132618
Description	TCF3/E47 and NEUROD2 work together to activate transcription that is dependent on E box. It is believed that NEUROD2 is a trans-acting factor that contributes to the creation and maintenance of the nervous system in mammals. The gene's promoter is activated by NEUROD2, which produces a positive feedback loop.
Other names	Atoh2, also known as Atonal homolog 2, is a protein that belongs to the basic helix-loop-helix (bHLH) family. It is also referred to as Neurogenic Differentiation Factor 6 (NDF6) or Nex1. The protein is encoded by the Math2 gene and is widely expressed in the developing nervous system. Atoh2 plays a crucial role in neurogenesis, the process by which new neurons are formed from neural stem cells. Studies have shown that it regulates the differentiation of neural progenitor cells into specific cell types, including neurons and glial cells. The protein also has an impact on the survival and maturation of newly formed neurons, suggesting that it is involved in various aspects of neural development. Additionally, Atoh2 has been found to be important for the formation of neural circuits, specifically in the development of the visual system. Due to its critical role in neural development, Atoh2 has been studied extensively in the context of neurological disorders. Abnormal expression of Atoh2 has been linked to conditions such as epilepsy, schizophrenia, and autism spectrum disorder. Overall, Atoh2 is a significant protein involved in the development and function of the nervous system, and its dysregulation can lead to various neurological disorders.
Source	Rabbit
Specificity	The NEUROD6 antibody has the ability to recognize and bind to the total NEUROD6 protein that is present in the body at natural levels. This means that it can effectively detect NEUROD6 without interference from other proteins or molecules. The antibody is therefore a valuable tool for researchers who wish to study the function and expression of NEUROD6 in various tissues and cells. By using the NEUROD6 antibody, scientists can gain a better understanding of the role that this protein plays in the development and function of the nervous system.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Dog;Bovine;
Antigen	NEUROD6
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	38 kDa)
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography for purification.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity).
Celluar localization	Nucleus;
UniPort	Q96NK8