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Rabbit Anti-Neuralized-1 Polyclonal Antibody#abs140480

Please note that the price provided is only for your reference. For more detailed pricing information, please do not hesitate to get in touch with our sales representative, Vecent. Western blot analysis Neuralized-1 using MCF7 whole cell lysates This product is for research use only, not for use...

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Description

Catalog-specification	Delivery time	USD price
abs140480-100ug	1-2 Weeks	301.0
abs140480-50ug	1-2 Weeks	201.0

Please note that the price provided is only for your reference. For more detailed pricing information, please do not hesitate to get in touch with our sales representative, Vecent.

Overview
catalog	abs140480
Other names	Neuralized homolog (Neu) is a protein that plays a crucial role in various biological processes. It is also known as Neuralized like protein 1 (Neuralized 1), Neuralized like protein 1A (Neuralized 1A), or RING finger protein 67 (RNF67). The Neu protein is involved in neural development and has been implicated in cellular signaling pathways. Its function is mediated through its RING finger domain, which is responsible for selectively ubiquitinating target proteins. This post-translational modification is essential for regulating protein degradation and turnover. Understanding the role of Neu in cellular processes holds promise for advancing our knowledge of development and disease mechanisms.
Source	Rabbit
Specificity	Endogenous levels of total Neuralized-1 can be detected by the Neuralized-1 Antibody. The antibody is designed to bind specifically with this protein, allowing for identification and measurement of its expression within the sample. By detecting endogenous levels, researchers can gather insights into the role this protein may play within the biological system being studied. This information can help to further our understanding of various physiological processes and pathologies.
Species Reactivity	Human
Antigen	Neuralized-1
Application	ELISA (peptide) 1:20000-1:40000, WB 1:1000, and IF/ICC 1:100-1:500 are the recommended dilutions for conducting various experiments. These dilutions enable accurate analysis and detection of specific proteins or molecules in samples. It is important to adhere to the specified dilution ranges to obtain reliable and reproducible results.
Immunogen	A peptide synthesized from Neuralized-1 of humans has been developed. The content produced is highly similar to the original text and is based on the information provided.
MW	62kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the process of peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to store the product at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles, as this can negatively impact its stability and quality.
Storage buffer	The provided information states that Rabbit IgG is stored in phosphate buffered saline at pH 7.4, with the presence of 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The storage temperature recommended is -20 °C, and the product remains stable for a duration of 12 months from the date of receipt.
Target
Background	Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
Tissue specificity	Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in an malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma (MB) compared with normal cerebellar tissues.
Posttranslational modification	Myristoylation is a determinant of membrane targeting.
Celluar localization	Plasma Membrane;
UniPort	O76050