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Phospho-c-Ret (Tyr981) Rabbit Polyclonal Antibody#abs140030

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Description

Catalog-specification	Delivery time	USD price
abs140030-100ug	1-2 Weeks	301.0
abs140030-50ug	1-2 Weeks	201.0

Overview
catalog	abs140030
Other names	REarranged content: - Proto-oncogene tyrosine-protein kinase receptor ret; Proto oncogene tyrosine protein kinase receptor ret; RET tyrosine-protein kinase receptor; RET Proto oncogene; RET ELE1; Oncogene RET; Ret Proto-oncogene; RET51; RET9; CDHR16; CDHF12; Cadherin related family member 16; Cadherin family member 12; CDHF 12; Cadherin-related family member 12; ELKS Fusion gene; HSCR 1; HSCR1; Multiple endocrine neoplasia and medullary thyroid carcinoma 1; MEN2B; MEN2A; MTC1; MTC 1; Hydroxyaryl protein kinase.
Source	Rabbit
Specificity	The c-Ret (Phospho-Tyr1015) Antibody is specifically designed to recognize and bind to the endogenous levels of c-Ret protein. It is highly sensitive and can detect c-Ret protein only when it is phosphorylated at Tyr1015. This antibody is a valuable tool for researchers studying the phosphorylation of c-Ret and its role in various cellular processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit
Antigen	c-Ret
Application	。WB1:1000-3000，IHC1:50-1:200，IF/ICC1:100-1:500，ELISA（）1:20000-1:40000。
Immunogen	c-Ret（1015）。，。
MW	175kDa
Properties
Concentration	1mg/ml
purification	The serum-derived antibody has undergone a rigorous purification process involving sequential chromatography on both phospho- and non-phospho-peptide affinity columns, resulting in a highly specific and effective product. The affinity purification method used involved utilizing the natural binding properties of peptides to separate out the desired antibody from other components of the serum. The end result is a purified rabbit serum antibody that can be used with confidence for a variety of research applications.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.
Tissue specificity	Positively regulated by NKX2-1, PHOX2B, SOX10 and PAX3.
Posttranslational modification	Autophosphorylated on C-terminal tyrosine residues upon ligand stimulation. Dephosphorylated by PTPRJ on Tyr-905, Tyr-1015 and Tyr-1062.Proteolytically cleaved by caspase-3. The soluble RET kinase fragment is able to induce cell death. The extracellular cell-membrane anchored RET cadherin fragment accelerates cell adhesion in sympathetic neurons.
Celluar localization	Cytosol;Endosome;Plasma Membrane;
UniPort	P07949