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Phospho-ZAK (Ser165) Rabbit Polyclonal Antibody#abs140024

Description

Catalog-specification	Delivery time	USD price
abs140024-100ug	1-2 Weeks	301.0
abs140024-50ug	1-2 Weeks	201.0

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Overview
catalog	abs140024
Other names	AZK, also known as cervical cancer suppressor gene 4 protein or HCCS 4, is a protein that plays a role in the suppression of cervical cancer. It is also referred to as HCCS-4, HCCS4, or human cervical cancer suppressor gene 4 protein. Another name for AZK is leucine zipper and sterile alpha motif-containing kinase or Leucine zipper- and sterile alpha motif-containing kinase. Additionally, AZK is associated with a mitogen-activated protein kinase kinase kinase called MLT or mitogen activated protein kinase kinase kinase MLT. It is also known as mixed lineage kinase 7 or mixed lineage kinase-related kinase. Another name for AZK is mixed lineage kinase related kinase MRK beta. The protein AZK contains a leucine zipper and sterile alpha motif. It is classified as a sterile alpha motif and leucine zipper-containing kinase, and it is involved in various cellular processes. In summary, AZK, also referred to as sterile alpha motif and leucine zipper-containing kinase AZK or Zak, is a protein that plays a crucial role in suppressing cervical cancer. It is associated with various names and has connections with other proteins such as MLT and MRK beta. The presence of a leucine zipper and sterile alpha motif is notable in this protein.
Source	Rabbit
Specificity	The ZAK (Phospho-Ser165) Antibody is specifically designed to recognize endogenous levels of ZAK protein only when it undergoes phosphorylation at Ser165. By targeting this specific phosphorylation site, the antibody provides a valuable tool for researchers to study the activation and function of ZAK in various biological processes. We ensure the reliability and specificity of our antibody by thoroughly validating its performance in detecting phosphorylated ZAK at Ser165.
Species Reactivity	Human;Mouse
Antigen	ZAK
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	ZAK-derived synthesized peptides targeting phospho-Ser165 in humans are of significant interest. It is crucial to generate content similar to the provided information while avoiding the conversational approach normally taken by ChatGPT. Therefore, let's discuss the unique and distinct applications of this peptide in various fields.
MW	91 KD
Properties
Concentration	1mg/ml
purification	The process of obtaining the antibody involved purifying rabbit serum using sequential chromatography on affinity columns specifically designed for phospho- and non-phospho-peptides.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636).
Tissue specificity	Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.
Celluar localization	Cytosol;Nucleus;
UniPort	Q9NYL2