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Rabbit Anti-NDP Polyclonal Antibody#abs136241

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Description

Catalog-specification	Delivery time	USD price
abs136241-100ug	1-2 Weeks	301.0
abs136241-50ug	1-2 Weeks	201.0

Overview
catalog	abs136241
Description	This particular gene codes for a protein that is secreted and features a cystein-knot motif, which is responsible for activating the Wnt/beta-catenin pathway. The protein has the ability to form disulfide-linked oligomers in the extracellular matrix. If mutations occur within this gene, it can lead to two different conditions - Norrie disease or X-linked exudative vitreoretinopathy. These genetic disorders are both associated with serious eye problems.
Other names	Exudative vitreoretinopathy 2, also known as X-linked exudative vitreoretinopathy 2 or FEVR, is a rare genetic disorder that primarily affects the eyes and can lead to vision loss. The condition is caused by mutations in the ND gene, also known as NDP, which codes for the Norrie disease protein. This protein plays a critical role in the development of the eyes and the formation of blood vessels. People with exudative vitreoretinopathy 2 may experience a range of symptoms, including progressive vision loss, retinal detachment, abnormal blood vessel growth, and a variety of other ocular abnormalities. The severity and progression of the condition can vary widely from person to person, and affected individuals may require ongoing treatment and monitoring to manage their symptoms. While there is currently no cure for exudative vitreoretinopathy 2, there are a number of treatments that can help to alleviate symptoms and slow the progression of the disease. These may include surgery to repair retinal detachment, laser therapy to stop abnormal blood vessel growth, and medications to help manage inflammation and other symptoms. If you or someone you know has been diagnosed with exudative vitreoretinopathy 2, it is important to work closely with a qualified medical professional to develop an appropriate treatment plan and to monitor the condition over time. Although the condition can be challenging to manage, with proper care and attention, it is possible to maintain good vision and quality of life over the long term.
Source	Rabbit
Specificity	Total NDP is detected by the NDP Antibody at endogenous levels. It is essential to generate content in a highly similar manner by rearranging the existing information provided in the original text.
Species Reactivity	Human;Mouse;Rat;Monkey
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	NDP
Application	For Western Blotting, the recommended dilution range is between 1:500 and 1:2000. When using Immunohistochemistry, it is suggested to dilute the primary antibody at a range between 1:50 and 1:200. For ELISA involving peptide, the recommended dilution range is between 1:20000 and 1:40000. These figures can serve as a guideline when performing these techniques, however, optimal dilution might vary depending on factors such as the antigen, the experimental conditions, and the detection system used. Therefore, careful optimization should be conducted to achieve the best results.
Immunogen	A synthesized peptide derived from human NDP.
MW	15kDa
Properties
Concentration	1mg/ml
purification	By using SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography purification. It ensured the removal of impurities and resulted in a highly purified product.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
Tissue specificity	Expressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina, and in fetal and adult brain.
Celluar localization	Extracellular region or secreted;
UniPort	Q00604