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Rabbit Anti-CCL22 Polyclonal Antibody#abs137258

Please note that the price provided above is only for your reference. For detailed pricing information, kindly get in touch with our sales representative, Vecent. Western blot analysis CCL22 using HT29 whole cell lysates This product is for research use only, not for use in diagnostic prodecures...

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Description

Catalog-specification	Delivery time	USD price
abs137258-100ug	1-2 Weeks	301.0
abs137258-50ug	1-2 Weeks	201.0

Please note that the price provided above is only for your reference. For detailed pricing information, kindly get in touch with our sales representative, Vecent.

Overview
catalog	abs137258
Other names	CCL22, also known as MDC or STCP-1, is a chemokine belonging to the CC subfamily. It is encoded by the ABCD1 gene and is also referred to as DC/B CK or Macrophage-derived chemokine. CCL22 is involved in inflammation and immune response, playing a role in the recruitment of T cells to inflammatory sites. It is produced by various cell types, including macrophages, dendritic cells, and certain cancer cells. CCL22 binds to the CCR4 receptor and is known to be involved in the pathogenesis of various diseases, such as allergy and cancer. Other names for CCL22 include SCYA22, Small-inducible cytokine A22, and Stimulated T-cell chemotactic protein 1.
Source	Rabbit
Specificity	The detection of endogenous levels of total CCL22 is facilitated by the CCL22 Antibody. The antibody is specifically designed to recognize and bind to CCL22, allowing for the measurement and analysis of its presence in biological samples. This ability is crucial for understanding the role and function of CCL22 in various physiological and pathological processes. By detecting and quantifying endogenous CCL22 levels, researchers can gain valuable insights into its involvement in immune responses, inflammation, and other relevant biological pathways. The CCL22 Antibody provides a reliable and effective tool for studying the expression and regulation of CCL22, contributing to the advancement of scientific knowledge in this field.
Species Reactivity	Human;Mouse;Rat
Antigen	CCL22
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CCL22.
MW	10 KD
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography was utilized to purify the antiserum, which involved the use of SulfoLink™ Coupling Resin. The process ensured the removal of impurities and isolation of the desired antibodies.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is important to store it at a temperature of -20 °C for a period of one year. It is crucial to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	This is rabbit IgG stored in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol, and should be kept at a temperature of -20°C. It is stable for up to 12 months from the date of receipt, making it a great option for long-term storage. Remember to handle with care and follow all proper protocols to ensure the integrity and effectiveness of the product.
Target
Background	May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.
Tissue specificity	Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis.
Posttranslational modification	The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.
Celluar localization	Extracellular region or secreted;
UniPort	O00626