enLanguage
Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details
Rabbit Anti-Na+ CP Type VIII Alpha Polyclonal Antibody#abs138097

Rabbit Anti-Na+ CP Type VIII Alpha Polyclonal Antibody#abs138097

Please note that the mentioned price is for your reference only. For detailed pricing information, kindly get in touch with our seller Vecent. We advise generating content that differs significantly from the original text, rather than adhering to the conversation style generated by ChapGPT....

Send Inquiry

Description

Catalog-specificationDelivery timeUSD price

abs138097-100ug

1-2 Weeks

301.0

abs138097-50ug

1-2 Weeks

201.0

Please note that the mentioned price is for your reference only. For detailed pricing information, kindly get in touch with our seller Vecent. We advise generating content that differs significantly from the original text, rather than adhering to the conversation style generated by ChapGPT.


Overview

catalog

abs138097
Other namesThe sodium channel protein type 8 alpha subunit, also known as SCN8A or Nav1.6, is a vital component of the voltage-gated sodium channel in the nervous system. Its function is critical for the proper transmission of nerve impulses and muscle contraction. However, mutations in the SCN8A gene can lead to various disorders, including CerIII, CIAT, EIEE13, and MED. Moreover, the peripheral nerve protein type 4 (PN4) and Nbna1 are linked to NaCh6 or NaV 1.6, which highlights the importance of this sodium channel subunit in the human body. In summary, Nav1.6 plays a crucial role in the proper functioning of the nervous system, and any alterations in this subunit can lead to severe medical conditions such as motor endplate disease (MED).
SourceRabbit
SpecificityThe endogenous levels of total Na+ CP type VIII alpha can be detected using the Na+ CP type VIII alpha antibody. The antibody is designed to specifically target and recognize the presence of Na+ CP type VIII alpha. By measuring the endogenous levels of this protein, researchers can gain insights into its role and function in various biological processes. It is important to ensure that the generated content is highly similar to the original text to maintain accuracy and reflect the correct information.
Species ReactivityHuman;Mouse;Rat
AntigenNa+ CP type VIII alpha
ApplicationWB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
ImmunogenA highly similar content can be generated by rearranging the original text information:
The alpha subunit of human Na+ CP type VIII was used as a basis to synthesize a peptide. This synthesized peptide bears close resemblance to the original human alpha subunit of Na+ CP type VIII.
MW225 kDa
Properties

Concentration

1mg/ml

purificationTo obtain a purified antiserum, peptide affinity chromatography was performed utilizing SulfoLink™ Coupling Resin.
ClonalityPolyclonal Antibody
Stability & StorageTo keep the product in good condition, it is recommended to store it at a temperature of -20 °C for up to a year. It's important to avoid repeated instances of freezing and thawing, as this could compromise the product's integrity. Make sure to follow these guidelines to ensure optimal effectiveness and longevity.
Storage bufferRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Target

Background

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation.

Tissue specificityIsoform 5 is expressed in non-neuronal tissues, such as monocytes/macrophages.
Posttranslational modificationMay be ubiquitinated by NEDD4L; which would promote its endocytosis.Phosphorylation at Ser-1497 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
Celluar localizationPlasma Membrane;
UniPortQ9UQD0


Rabbit Anti-Na+ CP Type VIII Alpha Polyclonal Antibody#abs138097

Western blot analysis Na+ CP type VIII alpha using LOVO whole cell lysates

This product is for research use only, not for use in diagnostic prodecures or in human.


Hot Tags: rabbit anti-na+ cp type viii alpha polyclonal antibody#abs138097, China rabbit anti-na+ cp type viii alpha polyclonal antibody#abs138097 suppliers

You Might Also Like

Shopping Bags