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Rabbit Anti-LBR Polyclonal Antibody#abs136868

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent. Western blot analysis of extracts of various celllines, using LBR antibody. This product is for research use only, not for use in diagnostic...

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Description

Catalog-specification	Delivery time	USD price
abs136868-100ug	1-2 Weeks	301.0
abs136868-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent.

Overview
catalog	abs136868
Description	The ERG4/ERG24 gene family encodes a protein that is responsible for anchoring the lamina and heterochromatin to the nuclear envelope inner membrane. This protein is located in the nucleus and may facilitate the interaction between lamin B and chromatin. Mutations in this gene have been linked to the autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing produces two transcript variants that code for the same protein. Overall, this gene plays a critical role in maintaining nuclear structure and function.
Other names	Lamin-B receptor (LBR), also known as DHCR14B or Integral nuclear envelope inner membrane protein, is an essential component of the nuclear envelope. It is encoded by the LBR_HUMAN gene and is also referred to as LMN2R or MGC9041. The LBR protein plays a crucial role in maintaining the structural integrity of the nuclear envelope and is involved in various cellular processes. The LBR gene is important for the proper localization of inner nuclear membrane proteins and provides a link between the nuclear lamina and chromatin. Mutations in the LBR gene can lead to a rare genetic disorder known as Pelger-Huet anomaly (PHA). PHA is characterized by abnormal-shaped neutrophil nuclei and can be associated with skeletal abnormalities. The function of LBR is not limited to its role in nuclear envelope organization. It has also been implicated in DNA replication and repair, regulation of gene expression, and cell differentiation. LBR interacts with several proteins involved in nuclear envelope dynamics and is thought to contribute to the functional integrity of the nucleus. Understanding the functions and molecular interactions of LBR is critical for unraveling the complex mechanisms underlying nuclear envelope organization and cellular processes. Further research on LBR may provide insights into the role of nuclear envelope proteins in human health and disease.
Source	Rabbit
Specificity	The detection of endogenous levels of total LBR is possible using the LBR Antibody. Can you please rearrange the content in a highly similar manner, taking into consideration the original information provided?
Species Reactivity	Human;Mouse
Predictive reaction species	Pig
Antigen	LBR
Application	The dilutions for Western blot (WB) range from 1:500 to 1:2000, for immunohistochemistry (IHC) they range from 1:50 to 1:200, and for ELISA using peptide it ranges from 1:20000 to 1:40000.
Immunogen	A synthesized peptide derived from human LBR.
MW	70kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography with SulfoLink™ Coupling Resin was utilized to purify the antiserum. Here's a text generated in a different style but based on the same information: To obtain a purified antiserum, an effective method employed was peptide affinity chromatography using SulfoLink™ Coupling Resin.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Anchors the lamina and the heterochromatin to the inner nuclear membrane.
Posttranslational modification	Phosphorylated by CDK1 in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. Phosphorylation of LBR and HP1 proteins may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle. Phosphorylated by SRPK1. In late anaphase LBR is dephosphorylated, probably by PP1 and/or PP2A, allowing reassociation with chromatin.
Celluar localization	Nucleus;
UniPort	Q14739