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Rabbit Anti-MYCNOS Polyclonal Antibody#abs138588

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Description

Catalog-specification	Delivery time	USD price
abs138588-100ug	1-2 Weeks	301.0
abs138588-50ug	1-2 Weeks	201.0

Overview
catalog	abs138588
Source	Rabbit
Specificity	The endogenous levels of total MYCNOS can be detected by the MYCNOS Antibody.
Species Reactivity	Human
Antigen	MYCNOS
Application	We have some important information to share with you regarding our products. Our recommended dilutions are as follows: for Western blotting, we suggest using a dilution of 1:1000-3000. For immunohistochemistry, a dilution of 1:200 is recommended. Finally, for ELISA using a peptide, we recommend a dilution range of 1:20000-1:40000. Please be sure to follow these dilution guidelines for optimal results. Thank you for choosing our products and we hope that this information will be helpful to you in your research.
Immunogen	A synthesized peptide derived from human MYCNOS.
MW	12 kDa
Properties
Concentration	1mg/ml
purification	Through the utilization of SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography for purification.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the product's integrity, it is advised to store it at a temperature of -20°C for a year. It is important to note that exposing the product to repeated freeze and thaw cycles should be avoided in order to prevent any potential damage.
Storage buffer	This solution contains Rabbit IgG dissolved in phosphate buffered saline with a pH of 7.4, along with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of approximately -20 °C, where it will remain stable for up to 12 months from the date of receipt.
Target
Background	By promoting phosphorylation at 'Ser-9', it inhibits GSK3B-mediated MYCN phosphorylation, thereby regulating the stability of MYCN in neuroblastoma cells (PubMed:24391509).
Tissue specificity	Expressed in the neuronal cells of the cerebrum and cerebellum, spermatocytes of the testis, pancreatic cells and also the heart. Expressed in both primary and metastatic neuroblastomas and in thyroid tumors (at protein level). Expression is associated with poor prognosis in neuroblastoma. Expressed in the fetal brain, lung, liver and kidney at varying low levels.
Celluar localization	Nucleus;
UniPort	P40205