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Rabbit Anti-NKAP Polyclonal Antibody#abs138589

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Description

Catalog-specification	Delivery time	USD price
abs138589-100ug	1-2 Weeks	301.0
abs138589-50ug	1-2 Weeks	201.0

Overview
catalog	abs138589
Other names	NF-kappa-B-activating protein, also known as NFKB activating protein or Nkap, is a crucial molecule involved in the activation of the nuclear factor kappa B (NF-kappaB) signaling pathway. In humans, it is encoded by the NKAP_HUMAN gene. This protein plays a vital role in modulating gene expression and immune responses by regulating the activity of NF-kappaB. Its functions are not limited to immune responses, as it also participates in other cellular processes such as cell growth, differentiation, and apoptosis. The identification and understanding of NKAP_HUMAN have provided valuable insights into the intricate mechanisms underlying NF-kappaB activation and its diverse functions in various biological processes.
Source	Rabbit
Specificity	Endogenous levels of total NKAP can be detected with the NKAP Antibody. This antibody is capable of recognizing the total NKAP present in the sample, indicating its high specificity.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit
Antigen	NKAP
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human NKAP.
MW	47 kDa
Properties
Concentration	1mg/ml
purification	Utilizing SulfoLink™ Coupling Resin, the antiserum underwent a purification process via peptide affinity chromatography. This resulted in a highly purified antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions for your product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles, as this can compromise its quality and efficacy. By following these guidelines, you can help to ensure that your product remains stable and effective for its intended use over an extended period of time.
Storage buffer	The Rabbit IgG is stored in phosphate buffered saline at a pH of 7.4. It contains 150mM NaCl and 0.02% sodium azide for preservation. Additionally, it is mixed with 50% glycerol to maintain its stability. It is recommended to store it at -20 °C for optimal preservation. This product has a shelf life of 12 months from the date of receipt.
Target
Background	Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter.
Celluar localization	Cytosol;Nucleus;
UniPort	Q8N5F7