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Rabbit Anti-MRP Polyclonal Antibody#abs138321

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Description

Catalog-specification	Delivery time	USD price
abs138321-100ug	1-2 Weeks	301.0
abs138321-50ug	1-2 Weeks	201.0

Overview
catalog	abs138321
Other names	MacMARCKS, also known as Macrophage enriched Myristoylated Alanine Rich C Kinase Substrate Like Protein, is a protein that plays a crucial role in macrophage function. It is a member of the MARCKS family, which includes MARCKS like protein 1 and MARCKS related protein. MacMARCKS is also referred to as MLP1, MRP, or MRP_HUMAN. This protein is involved in regulating cellular processes by modulating the activity of protein kinases. It contains a myristoylation site and an alanine-rich domain, which are important for its localization and function within macrophages. The myristoylation site enables the protein to anchor to the cell membrane, while the alanine-rich domain facilitates interactions with other proteins and signaling molecules. MacMARCKS is predominantly expressed in macrophages, specialized immune cells that play a crucial role in host defense and inflammatory responses. It is responsible for coordinating cellular processes, such as phagocytosis, endocytosis, and cytokine secretion. Through its interactions with protein kinases, MacMARCKS regulates the dynamics of the actin cytoskeleton, which is essential for macrophage function. The role of MacMARCKS in macrophages suggests its involvement in various pathological conditions, including inflammation, infection, and cancer. Dysregulation of MacMARCKS expression or activity can impact macrophage function and contribute to the development of disease. Therefore, understanding the functions and regulatory mechanisms of MacMARCKS is important for advancing our knowledge of macrophage biology and developing potential therapeutic strategies.
Source	Rabbit
Specificity	The MRP Antibody has the ability to detect the total amount of MRP present in an organism. This means that the antibody can identify and bind to the endogenous levels of MRP, making it a useful tool for researchers studying this protein. By using the MRP Antibody, scientists can gain insights into the role of MRP in various biological processes and potentially develop new therapies for related diseases.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	MRP
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human MRP.
MW	20 kDa
Properties
Concentration	1mg/ml
purification	Utilizing SulfoLink™ Coupling Resin, the purification of the antiserum was accomplished through peptide affinity chromatography. Please devise a similar variant of the provided information by rearranging the content while maintaining its original meaning.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of the product, it is recommended to keep it stored at a temperature of -20°C for up to one year. It is important to avoid exposing the product to repeated freeze/thaw cycles, as this can compromise its quality. Taking these precautions will help to maintain the integrity and effectiveness of the product for its intended use.
Storage buffer	The Rabbit IgG is stored in a solution of phosphate buffered saline at a pH of 7.4, containing 150mM NaCl and 0.02% sodium azide. Additionally, the solution contains 50% glycerol as a stabilizing agent. It is recommended to store the solution at a temperature of -20 °C. The solution is considered stable for a period of 12 months starting from the date of receipt of the product.
Target
Background	Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).
Posttranslational modification	Phosphorylation at Ser-120 and Thr-178 are non-redundantly catalyzed by MAPK8 in vivo. Phosphorylation at Thr-148 is preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the absence of MAPK8 (By similarity).
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P49006