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Rabbit Anti-TF2A2 Polyclonal Antibody#abs138324

Please note that the mentioned price serves as a reference only. For more specific pricing information, kindly reach out to our seller Vecent. Western blot analysis TF2A2 using K562 whole cell lysates This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specification	Delivery time	USD price
abs138324-100ug	1-2 Weeks	301.0
abs138324-50ug	1-2 Weeks	201.0

Please note that the mentioned price serves as a reference only. For more specific pricing information, kindly reach out to our seller Vecent.

Overview
catalog	abs138324
Other names	The protein known as General transcription factor IIA, or TFIIA for short, plays a crucial role in the regulation of gene expression in eukaryotic cells. Specifically, TFIIA is a complex of proteins consisting of multiple subunits, including General transcription factor IIA subunit 2, also known as TFIIA-12 or TFIIA gamma. TFIIA-12 is a small protein with a molecular weight of approximately 12 kilodaltons, which is important for its function as a transcription initiation factor. This protein is encoded by the gene gtf2a2 in humans and is also known by the aliases HsT18745, TF2A2, and TFIIAS. TFIIA-12 is essential for the recruitment of RNA polymerase II to the promoter region of a gene, which is the first step in the process of transcription. It specifically interacts with the TATA box, which is a conserved DNA element found in many promoters. In addition to its role in transcription initiation, TFIIA-12 has also been implicated in other aspects of gene expression, including chromatin remodeling and mRNA processing. Its functional diversity reflects the complexity of the regulatory network that controls gene expression in eukaryotes. Overall, TFIIA-12 is a critical component of the transcription machinery that allows for the precise regulation of gene expression in response to different physiological and environmental cues. Its importance is underscored by the fact that mutations in the gtf2a2 gene have been associated with a variety of human diseases, including cancer and developmental disorders.
Source	Rabbit
Specificity	The TF2A2 Antibody is highly effective in detecting the total levels of endogenous TF2A2 in a sample. Its specificity and sensitivity make it an ideal tool for analyzing the expression of this protein in various physiological and pathological conditions. The Antibody can generate accurate results, allowing researchers to gain a deeper understanding of the biological processes involving TF2A2.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse;
Antigen	TF2A2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human TF2A2.
MW	12 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the peptide affinity chromatography process to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to note that repeated freeze/thaw cycles should be avoided, as this can negatively impact the quality of the product. By following these storage guidelines, you can ensure that your product remains in optimal condition and maintains its effectiveness for the duration of its shelf life.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.
Celluar localization	Nucleus;
UniPort	P52657