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Rabbit Anti-MMP-8 Polyclonal Antibody#abs131549

Description

Catalog-specification	Delivery time	USD price
abs131549-100ug	1-2 Weeks	301.0
abs131549-50ug	1-2 Weeks	201.0

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Overview
catalog	abs131549
Description	The enzyme's catalytic zinc ion is bound by a conserved cysteine found in the cysteine-switch motif, resulting in inhibition. The enzyme is activated when the cysteine dissociates from the zinc ion after the release of the activation peptide.
Other names	Collagenase 1, also known as CLG1, is an enzyme that plays a crucial role in the breakdown of collagen. It is often referred to as matrix metalloproteinase-8 (MMP-8) or neutrophil collagenase, which highlights its association with neutrophils and its role in connective tissue remodeling. PMNL CL, PMNL collagenase or PMNLCL are also alternate names for this enzyme. The gene coding for this enzyme is called MMP8_HUMAN. When collagen needs to be broken down in vivo, collagenase 1 is produced by neutrophils and other cells to degrade collagen. The enzyme cleaves specific peptide bonds within the triple helix structure of collagen and thus alters its shape and function. This can lead to normal tissue remodeling or pathological tissue destruction. Collagenase 1 can serve as an indicator for various diseases, including arthritis and periodontitis. Since its level increases in response to inflammatory stimuli, it can be used as a biomarker for these conditions and for monitoring the efficacy of treatment. In summary, collagenase 1, also known as CLG1, is an enzyme that breaks down collagen and is involved in connective tissue remodeling. It is produced by neutrophils and other cells and can serve as a biomarker for various diseases.
Source	Rabbit
Specificity	The ability of the MMP-8 Antibody to identify the overall MMP-8 levels inside the body is well-established.
Species Reactivity	Human;Mouse;Rat
Antigen	MMP-8
Application	For western blotting, dilute the primary antibody at a concentration of 1:500 to 1:2000. When performing immunohistochemistry on paraffin-embedded tissue, use a dilution of 1:50 to 1:200. The antibody can also be utilized for flow cytometry, immunohistochemistry on frozen sections, immunocytochemistry/immunofluorescence, and ELISA using peptide antigens. For these applications, dilutions of 1:50 to 1:200, 1:100 to 1:500, and 1:20000 to 1:40000 may be used, respectively.
Immunogen	A synthesized peptide derived from human MMP-8.
MW	53 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. Please provide a highly similar interpretation by rephrasing the original information.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing, as this can adversely affect its properties and efficacy. Therefore, it is advisable to handle and store the product with care, following the guidelines provided to ensure optimal results and maximum shelf life.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Can degrade fibrillar type I, II, and III collagens.
Tissue specificity	Neutrophils.
Celluar localization	Extracellular region or secreted;
UniPort	P22894

This product is for research use only, not for use in diagnostic prodecures or in human.

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