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Rabbit Anti-MLF1 Polyclonal Antibody#abs141271

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Description

Catalog-specification	Delivery time	USD price
abs141271-100ug	1-2 Weeks	301.0
abs141271-50ug	1-2 Weeks	201.0

Overview
catalog	abs141271
Other names	MLF1, also known as Myelodysplasia-myeloid leukemia factor 1, is a crucial protein that plays a vital role in the progression of cancer cells in humans. It is associated with the development of myelodysplastic syndromes and acute myeloid leukemia. The MLF1 gene has several variants, including variant 1, variant 2, and variant 3. The MLF1 protein interacts with other proteins to form a complex that regulates various cellular processes, including cell growth and apoptosis. Mutations in the MLF1 gene are known to cause abnormal cellular processes, leading to the development of cancer. Understanding the molecular mechanisms of MLF1 function is crucial for developing targeted therapies for myelodysplasia and leukemia.
Source	Rabbit
Specificity	The total MLF1 levels can be detected by the MLF1 Antibody, which specifically recognizes the endogenous MLF1 protein. By utilizing this antibody, researchers can accurately measure the levels of MLF1 present within samples.
Species Reactivity	Human;Mouse
Antigen	MLF1
Application	For Western Blot, the recommended antibody dilution ranges from 1:500 to 1:1000. In the case of Immunofluorescence (IF) or Immunocytochemistry (ICC), the antibody should be diluted at a ratio of 1:100 to 1:500. For ELISA using peptide antigens, the optimal antibody dilution is between 1:20000 and 1:40000. It is essential to carefully adjust the dilution factors to ensure accurate and reliable results.
Immunogen	A synthesized peptide.
MW	30 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was carried out through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to store at a temperature of -20 °C for a duration of one year while ensuring to prevent repeated freeze/thaw cycles.
Storage buffer	Our rabbit IgG is stored in a solution of phosphate buffered saline with a pH of 7.4. It also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store it at -20 °C for optimal stability. The product is guaranteed to remain stable for 12 months from the date of receipt.
Target
Background	Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Tissue specificity	Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
Posttranslational modification	Phosphorylation is required for binding to YWHAZ.
Celluar localization	Nucleus;
UniPort	P58340