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Rabbit Anti-MIB1 Polyclonal Antibody#abs137817

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Description

Catalog-specification	Delivery time	USD price
abs137817-100ug	1-2 Weeks	301.0
abs137817-50ug	1-2 Weeks	201.0

Overview
catalog	abs137817
Other names	Here are some alternative ways to rearrange the given content: 1. Mind bomb homolog 1, also known as Mib1, is an E3 ubiquitin protein ligase that interacts with DAPK-interacting protein 1, or Dip1. It is encoded by the KIAA1323 gene and contains a zinc finger ZZ type with ankyrin repeat domain, which is also found in another protein called ZZANK2. Mib1 plays a role in cardiac development and is associated with left ventricular noncompaction cardiomyopathy (LVNC7). 2. DIP-1, or Dip1, is a protein that interacts with the E3 ubiquitin protein ligase MIB1, also known as mind bomb homolog 1. MIB1 is encoded by the KIAA1323 gene and contains a ZZ type zinc finger domain with ankyrin repeats, which is also present in the protein ZZANK2. MIB1 plays a role in ubiquitination and turnover of Notch signaling pathway components, and mutations in this gene have been linked to left ventricular noncompaction cardiomyopathy (LVNC7). 3. The protein MIB1, also called mindbomb E3 ubiquitin protein ligase 1, is encoded by the KIAA1323 gene and contains a zinc finger ZZ type with ankyrin repeat domain, like the protein ZZANK2. MIB1 interacts with DIP1, or DAPK-interacting protein 1, and is involved in the ubiquitination and degradation of Notch pathway proteins. Mutations in MIB1 have been associated with left ventricular noncompaction cardiomyopathy (LVNC7). 4. Zinc finger ZZ type with ankyrin repeat domain protein 2, or ZZANK2, is a protein domain that is found in several proteins including the E3 ubiquitin protein ligase MIB1, or mind bomb homolog 1. MIB1 interacts with DIP1, or DAPK-interacting protein 1, and plays a role in regulating the Notch signaling pathway by ubiquitinating and promoting the turnover of key signaling components. Mutations in MIB1 have been implicated in the development of left ventricular noncompaction cardiomyopathy (LVNC7). 5. LVNC7 is a genetic disorder characterized by left ventricular noncompaction of the heart muscle. Mutations in the KIAA1323 gene, which encodes the protein MIB1 or mind bomb homolog 1, have been associated with this condition. MIB1 interacts with DIP1, or DAPK-interacting protein 1, and functions as an E3 ubiquitin protein ligase that targets key components of the Notch signaling pathway for degradation. MIB1 contains a zinc finger ZZ type ankyrin repeat domain, similar to the protein ZZANK2.
Source	Rabbit
Specificity	The MIB1 Antibody is capable of detecting the total amount of endogenous MIB1 present within a sample. The generated content should closely mirror the original text while also staying true to the provided information.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	MIB1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human MIB1.
MW	110 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the purification process of the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	One year storage at -20 °C is recommended to maintain product quality. It is important to avoid subjecting the product to repeated freeze-thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.
Tissue specificity	Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined.
Posttranslational modification	Ubiquitinated; possibly via autoubiquitination (By similarity). Ubiquitinated; this modification is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock.
Celluar localization	Cytoskeleton;Cytosol;Plasma Membrane;
UniPort	Q86YT6