Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-CDK5R1 Polyclonal Antibody#abs133586

Please note that the price mentioned above is just for your reference. For detailed pricing information, please get in touch with our seller, Vecent. It is essential to reiterate that any content generated by ChapGPT must be avoided, and instead, the focus should be on generating original text...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs133586-100ug	1-2 Weeks	301.0
abs133586-50ug	1-2 Weeks	201.0

Overview
catalog	abs133586
Other names	CDK5 activator 1, also known as CD5R1_HUMAN or p35, is a regulatory subunit of cyclin-dependent kinase 5 (CDK5). It plays a crucial role in neuronal CDK5 activation and acts as a regulatory partner for CDK5 kinase. CDK5 activator 1 is also referred to as p25, p23, or NCK 5A. It is a tau protein kinase II 23 kDa subunit and functions as a TPKII regulatory subunit. The primary function of CDK5 activator 1 is to interact with CDK5 and enhance its kinase activity. This regulatory subunit ensures the proper activation and functioning of CDK5, which is essential for various neuronal processes, such as neuronal migration, axon guidance, and synaptic plasticity. CDK5 activator 1 is crucial for the development and maintenance of the nervous system. Its dysregulation has been associated with neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. Abnormal levels of CDK5 activator 1, specifically the cleaved form p25, can lead to hyperactivation of CDK5, resulting in neuronal death and cognitive impairments. Research on CDK5 activator 1 and its role in neurodegenerative diseases is ongoing, aiming to understand its molecular mechanisms and explore potential therapeutic interventions. By manipulating the regulatory function of CDK5 activator 1, it may be possible to modulate CDK5 activity and mitigate the pathological consequences associated with neurodegenerative disorders.
Source	Rabbit
Specificity	The total CDK5R1 levels can be detected using the CDK5R1 Antibody, which specifically identifies the endogenous levels of CDK5R1 protein.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Dog;Horse;Bovine
Antigen	CDK5R1
Application	。/，1:1001:500。（ELISA），，1:200001:40000。
Immunogen	A synthesized peptide.
MW	38 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed for peptide affinity chromatography in order to purify the antiserum. Please generate a different content by rearranging the given information while ensuring it remains true to the original text.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing. By following these guidelines, the product can be preserved in its optimal condition for an extended period of time.
Storage buffer	The rabbit IgG is stored in a solution of phosphate buffered saline with a pH of 7.4. Additionally, the solution contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol to ensure stability. It is recommended to store the solution at a temperature of -20 °C to maintain its quality. The rabbit IgG solution is guaranteed to be stable for a period of twelve months from the date of receipt.
Target
Background	p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.
Tissue specificity	Brain and neuron specific.
Posttranslational modification	The p35 form is proteolytically cleaved by calpain, giving rise to the p25 form. P35 has a 5 to 10 fold shorter half-life compared to p25. The conversion results in deregulation of the CDK5 kinase: p25/CDK5 kinase displays an increased and altered tau phosphorylation in comparison to the p35/CDK5 kinase in vivo (By similarity).Myristoylated. A proper myristoylation signal is essential for the proper distribution of p35.Ubiquitinated. Degradation of p35 by proteasome results in down-regulation of CDK5 activity. During this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation.Phosphorylation at Ser-8 and Thr-138 by CDK5 prevents calpain-mediated proteolysis.
Celluar localization	Cytosol;Nucleus;Plasma Membrane;
UniPort	Q15078