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Rabbit Anti-MAP3K9 Polyclonal Antibody#abs138328

Description

Catalog-specification	Delivery time	USD price
abs138328-100ug	1-2 Weeks	301.0
abs138328-50ug	1-2 Weeks	201.0

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Overview
catalog	abs138328
Other names	There are several protein kinases that play important roles in various cellular pathways. MEKK10 and MEKK9, for example, are mitogen activated protein kinase kinase kinases that are involved in the activation of downstream signaling cascades. On the other hand, mixed lineage kinase 1 and 2 have both tyrosine and serine/threonine specificities and are important in regulating cell growth and differentiation. Additionally, nonreceptor_type serine/threonine kinase derived from MKN28 and PRKE1 also play important roles in cellular signaling pathways. Another notable protein kinase is Protein kinase MST, which is involved in the regulation of cell proliferation and apoptosis. Together, these protein kinases have diverse functions and are essential in maintaining proper cellular homeostasis.
Source	Rabbit
Specificity	The total MAP3K9 levels in the body can be effectively detected using the MAP3K9 Antibody. This antibody specifically targets and binds to the endogenous levels of MAP3K9 present in the biological system. By utilizing this antibody, researchers can accurately determine the overall expression of MAP3K9 protein.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	MAP3K9
Application	。WB1:1000-3000，IHC1:200，ELISA（）1:20000-1:40000。
Immunogen	A synthesized peptide derived from human MAP3K9.
MW	121 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. Similarly, the antiserum was subjected to a process of cleaning, where the resin was utilized in order to remove any unnecessary or extraneous matter from the substance. This process of purification ensured that the antiserum was of high quality and met the required standards for its intended use.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for up to one year. It is important to avoid exposing the product to repeated freeze/thaw cycles as this can have a negative impact on its efficacy. Keep in mind that proper storage is key to ensuring the longevity of the product.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it is suspended in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20 °C, and it remains stable for 12 months from the date of receipt.
Target
Background	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Tissue specificity	Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
Posttranslational modification	Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site. Autophosphorylation also occurs on Thr-304 and Ser-308.
UniPort	P80192