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Rabbit Anti-LTK Polyclonal Antibody#abs133448

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Description

Catalog-specification	Delivery time	USD price
abs133448-100ug	1-2 Weeks	301.0
abs133448-50ug	1-2 Weeks	201.0

Overview
catalog	abs133448
Other names	Protein tyrosine kinase 1, also known as leukocyte receptor tyrosine kinase or leukocyte tyrosine kinase receptor, is designated by various names such as Ltk, LTK_HUMAN, TYK1, and TYK 1. This kinase plays a crucial role in leukocyte functioning and signaling pathways. Its activity is essential for regulating cellular processes and immune responses. By rearranging the given information, we can understand the significance of leukocyte receptor tyrosine kinase in different biological contexts.
Source	Rabbit
Specificity	The total LTK levels can be accurately detected using the LTK Antibody, which is capable of detecting endogenous levels of LTK. To provide a highly similar content, the original text information can be rearranged as follows: The LTK Antibody is designed to detect the endogenous total LTK levels effectively.
Species Reactivity	Human;Mouse
Antigen	LTK
Application	The recommended dilution for WB is typically between 1:500 to 1:1000, while for IF/ICC it is generally 1:100 to 1:500. When considering ELISA using peptide samples, a dilution range of 1:20000 to 1:40000 is commonly used.Please note that the generated content is written in a different style and should not be mistaken for the original text from the model.
Immunogen	A synthesized peptide.
MW	92 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Please make sure to store at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to repeated freezing and thawing cycles.
Storage buffer	The storage condition for Rabbit IgG is as follows: it should be stored at -20 °C in a solution containing phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This particular antibody is stable for a period of 12 months from the date it was received.
Target
Background	This protein is a receptor that possesses tyrosine-protein kinase activity, although its exact function is still unknown. In chimeric protein studies, where its extracellular region was replaced with that of various growth factor receptors such as EGFR and CSFIR, it was discovered that this protein promotes growth, particularly neurite outgrowth, and cell survival. Signaling seems to involve the PI3 kinase pathway. Furthermore, it plays a role in regulating the secretory pathway that involves endoplasmic reticulum (ER) export sites (ERESs) and transportation from ER to Golgi.
Tissue specificity	Expressed in non-hematopoietic cell lines and T- and B-cell lines.
Celluar localization	Plasma Membrane;
UniPort	P29376