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Rabbit Anti-OXT Polyclonal Antibody#abs137616

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Description

Catalog-specification	Delivery time	USD price
abs137616-100ug	1-2 Weeks	301.0
abs137616-50ug	1-2 Weeks	201.0

Overview
catalog	abs137616
Other names	Neurophysin 1, also known as neurophysin I, is encoded by the genes MGC126890 and MGC126892. This protein is involved in the synthesis and secretion of oxytocin (OT), a neuropeptide that plays a key role in social bonding and reproductive functions. OT is produced as a prepropeptide, which is processed into the mature peptide and a carrier protein known as neurophysin 1. The oxytocin-neurophysin 1 complex is transported down axons and stored in the posterior pituitary gland, where it can be released into the bloodstream in response to various stimuli. Once released, OT acts on specific receptors in target tissues such as the uterus and mammary glands, promoting uterine contractions during labor and milk ejection during lactation. Research has also implicated OT in social behaviors such as trust, empathy, and pair bonding. Dysregulation of OT signaling has been associated with several psychiatric disorders, including autism, schizophrenia, and depression. As such, understanding the mechanisms underlying OT synthesis and release may have important implications for the treatment of these disorders.
Source	Rabbit
Specificity	The detection of endogenous levels of total OXT is possible with the OXT Antibody. It can accurately measure the presence of OXT in the system. By utilizing this antibody, researchers can gain insights into the overall levels of OXT present.
Species Reactivity	Human
Antigen	OXT
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human OXT.
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Please make sure to avoid repeated freeze/thaw cycles and store the product at -20 °C for one year.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4, 150mM of NaCl, 0.02% of sodium azide, and 50% glycerol. It is recommended to be stored at -20°C and will remain stable for up to 12 months from the date of receipt.
Target
Background	Neurophysin 1 specifically binds oxytocin.
Celluar localization	Extracellular region or secreted;
UniPort	P01178