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Rabbit Anti-LGALS3 Polyclonal Antibody#abs135940

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Description

Catalog-specification	Delivery time	USD price
abs135940-100ug	1-2 Weeks	301.0
abs135940-50ug	1-2 Weeks	201.0

Overview
catalog	abs135940
Description	Galectins are a group of animal lectins that are known for their ability to bind to b-galactoside sugars. They are involved in several cellular processes, such as cell-to-cell adhesion, interactions with the extracellular matrix, pre-mRNA splicing, and apoptosis. Galectin-3, also known as Mac-2, hMac-2, GALBP, CBP35 or LGALS3, is a protein that contains a single carbohydrate binding domain that can bind to glycoconjugates containing galactose. Galectin-3 is commonly found in various cell types, such as intestinal and colonic epithelial cells, papillary and follicular carcinomas, inflammatory macrophages, neoplastic astrocytes, and B and T lymphocytes. Studies have shown that upregulated expression of galectin-3 is linked to cancer progression and metastasis. It is also involved in mediating the endocytosis of ∫1 Integrins in a lactose-dependent manner and is associated with thyroid malignancy and Crohn's disease. Furthermore, galectin-3 is a useful marker in diagnosing cases involving Hurthle cell adenomas and carcinomas. Its significance in the field of cancer research highlights the importance of understanding the role of galectin-3 in cellular functions and its potential as a therapeutic target.
Other names	Galectin-3, also known as carbohydrate binding protein 35 or CBP 35, is a lectin with a molecular weight of 35 kDa. It is a carbohydrate-binding protein that plays a role in various biological processes. Other names for galectin-3 include Gal-3, GAL3, Galactose-specific lectin 3, Galactoside-binding protein, GALBP, Galectin 3 internal gene, included, Galectin-3, Galectin3, GALIG, GBP, IgE binding protein, IgE-binding protein, L 31, L 34, L-31, L-34 galactoside-binding lectin, Laminin-binding protein, Lectin L-29, Lectin, galactose binding, soluble 3, LEG3_HUMAN, LGALS2, LGALS3, MAC 2 antigen, Mac-2, Mac-2 antigen, MAC2, Macrophage galactose-specific lectin, and MGC105387.
Source	Rabbit
Specificity	The LGALS3 Antibody has the ability to identify total LGALS3 levels in the body. Its application is suitable for detecting endogenous levels of this protein. The content can be rephrased to emphasize the antibody's ability to recognize LGALS3 in its entirety and provide useful information for researchers studying this protein.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Horse;
Antigen	LGALS3
Application	The recommended dilutions for using this antibody are as follows: for Western Blotting, it is suggested to dilute the antibody at a ratio of 1:500-1:2000; for Immunohistochemistry, the suggested dilution is 1:50-1:200; for Immunofluorescence/Immunocytochemistry, the dilution ratio should be 1:100-1:500; and for ELISA (peptide), it is advised to dilute at a ratio of 1:20000-1:40000. These dilution ratios have been optimized for the best result, and it is recommended to perform a titration experiment to determine the optimal antibody dilution for specific applications.
Immunogen	A synthesized peptide derived from human LGALS3.
MW	26kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.
Tissue specificity	A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.
Celluar localization	Extracellular region or secreted;Mitochondrion;Nucleus;Plasma Membrane;
UniPort	P17931