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Rabbit Anti-BCHE Polyclonal Antibody#abs135939

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Description

Catalog-specification	Delivery time	USD price
abs135939-100ug	1-2 Weeks	301.0
abs135939-50ug	1-2 Weeks	201.0

Overview
catalog	abs135939
Description	Suxamethonium sensitivity is attributed to mutant alleles found at the BCHE locus. When individuals are homozygous for these alleles, they experience prolonged apnea after being administered the muscle relaxant suxamethonium during surgical procedures. This is due to the low activity of pseudocholinesterase in their serum, which also has an atypical behavior towards its substrate. It is important to note that in the absence of the muscle relaxant, homozygotes do not face any known disadvantages.
Other names	Butyrylcholine esterase, also known as acylcholine acylhydrolase, is an important enzyme that functions to degrade acetylcholine in the human body. Other names for this enzyme include CHE1, CHE2, CHLE_HUMAN, choline esterase II, cholinesterase 1, pseudocholinesterase, and pseudocholinesterase E1. Serum cholinesterase 2 is also an alternate name for this enzyme. Acetylcholine plays a critical role in the nervous system, particularly in the transmission of nerve impulses and the regulation of muscle movement. Its breakdown is necessary for proper functioning, and butyrylcholine esterase is one of the key enzymes responsible for this process. Butyrylcholine esterase has two isoforms, CHE1 and CHE2, that are localized to different tissues in the body. Studies have suggested that genetic variations in these isoforms may affect individual responses to certain drugs and toxins. This makes understanding the function and regulation of this enzyme critical for personalized medicine and drug development. Overall, butyrylcholine esterase plays a vital role in the regulation of acetylcholine levels in the body. Its importance in the nervous and muscular systems, as well as its potential clinical implications, make it an intriguing enzyme for continued study.
Source	Rabbit
Specificity	The BCHE Antibody has the ability to recognize and bind to the total BCHE present within the body's natural levels. This characteristic makes it a valuable tool for conducting research and investigations into the role and function of BCHE.
Species Reactivity	Human;Mouse;Rat
Antigen	BCHE
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human BCHE.
MW	68kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure preservation for one year, store at a temperature of -20 °C and avoid subjecting the item to multiple freeze/thaw cycles. It is crucial to follow these guidelines to maintain the product's condition.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Tissue specificity	Detected in blood plasma (at protein level). Present in most cells except erythrocytes.
Posttranslational modification	N-glycosylated. No other PTM detected (PubMed:20946535). The major N-glycan structures are of the complex diantennary type with 1 and 2 N-acetylneuraminic acid molecules (Neu5Ac) making up approximately 33% and 47% of the total N-glycans, respectively. Only low amounts of fucosylated diantennary N-glycans are detected (approximately 2%). Triantennary N-glycans with or without fucose amount to approximately 13%, whereas 5% of the total N-glycans are of the oligomannosidic or hybrid type.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;Nucleus;
UniPort	P06276