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Rabbit Anti-NUDC Polyclonal Antibody#abs137668

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Description

Catalog-specification	Delivery time	USD price
abs137668-100ug	1-2 Weeks	301.0
abs137668-50ug	1-2 Weeks	201.0

Overview
catalog	abs137668
Other names	NPD011, also known as HNUDC or MNUDC, is a protein that plays a crucial role in nuclear distribution. It is a homolog of the nuclear distribution gene C found in Aspergillus nidulans. This protein, also referred to as NudC or nuclear migration protein nudC, is involved in the transport of nuclear components within cells. The significance of NPD011 lies in its contribution to the proper distribution and positioning of the nucleus, ensuring essential cellular processes. By rearranging and organizing various cellular components, NPD011 facilitates optimal cell function. Numerous studies have identified the importance of this protein in various cellular mechanisms, such as cell division, organelle movement, and development. Encoded by the NPD011 gene, this homologous protein exhibits structural similarities to the NPD011 protein found in Aspergillus nidulans. The gene is commonly referred to as Nuclear distribution gene C homolog or simply Nuclear distribution gene C. Through evolutionary conservation, NPD011 maintains functional equivalence to its homolog, playing a similar role in nuclear distribution across different organisms. Also known as SIG 92 or SIG92, the NPD011 protein aids in the regulation of nuclear transport processes. Its activity is vital for ensuring the proper localization of genetic material and other essential cellular components. Dysfunction or aberrant expression of NPD011 can disrupt nuclear distribution, leading to detrimental effects on cell viability and function. In summary, NPD011, or HNUDC/MNUDC, is an important protein involved in nuclear distribution. Its homology to the nuclear distribution gene C in Aspergillus nidulans underscores its significance in cellular processes. This protein, also known as NudC or SIG 92, contributes to the proper positioning of the nucleus and facilitates various essential cellular mechanisms.
Source	Rabbit
Specificity	The presence of total NUDC can be accurately detected using the NUDC Antibody, which is capable of detecting endogenous levels of the protein.
Species Reactivity	Human
Antigen	NUDC
Application	，。 ELISA (peptide)：1:20000-1:40000, WB：1:1000-3000, IF/ICC：1:200-1:500。。 WB 1:1000-3000，IF/ICC 1:200-1:500。ELISA (peptide)，1:20000-1:40000。，。
Immunogen	A synthesized peptide derived from human NUDC.
MW	42 kDa
Properties
Concentration	1mg/ml
purification	Utilizing the SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. This process ensured that the resulting antiserum remained highly potent and effective.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to note that the product should not be subjected to repeated cycles of freezing and thawing in order to prevent degradation.
Storage buffer	This solution contains Rabbit IgG in a phosphate buffered saline (pH 7.4) with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20 °C and is stable for a period of 12 months from the date of receipt.
Target
Background	Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
Tissue specificity	Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.
Posttranslational modification	Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases.
Celluar localization	Cytoskeleton;Cytosol;Nucleus;
UniPort	Q9Y266