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Rabbit Anti-LETMD1 Polyclonal Antibody#abs136390

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Description

Catalog-specification	Delivery time	USD price
abs136390-100ug	1-2 Weeks	301.0
abs136390-50ug	1-2 Weeks	201.0

Overview
catalog	abs136390
Description	This particular gene is responsible for encoding a protein found in the outer membrane of mitochondria. Its potential involvement in tumorigenesis is thought to be linked to its ability to negatively regulate the p53 tumor suppressor gene. Researchers have identified alternative spliced transcript variants of this gene. This information was sourced from RefSeq in August 2011. To create a highly similar content, the provided text can be rearranged as follows: "The protein encoded by this gene is located in the outer membrane of mitochondria and is involved in various cellular processes. Its potential role in tumorigenesis is believed to stem from its ability to negatively influence the expression of the p53 tumor suppressor gene. Scientists have discovered different variants of this gene resulting from alternative splicing. These findings were reported in August 2011 by RefSeq."
Other names	The gene 1110019O13Rik is associated with cervical cancer, specifically with the proto-oncogene proteins Cervical cancer 1 and 2. Additionally, it is also known as DKFZp586A011 and HCRR2. The protein HCCR1, or HCCR 2, is involved in regulation of the tumor protein TP53. Another alternative name for this gene is LETM1 domain containing 1. While the original content may seem technical, it provides valuable information on the role of this gene in the development of cervical cancer and its potential as a therapeutic target.
Source	Rabbit
Specificity	The total LETMD1 levels can be efficiently detected by the LETMD1 Antibody, which specifically recognizes the endogenous levels of LETMD1 protein. To provide a highly similar content based on the original text information, here it is: The endogenous levels of total LETMD1 can be accurately identified using the LETMD1 Antibody. This particular antibody is designed to specifically detect and bind to the LETMD1 protein present within the cell. By utilizing this antibody, researchers can reliably measure and quantify the amount of LETMD1 protein in a sample. This enables a better understanding of the role and function of LETMD1 in various biological processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Sheep;Bovine;Dog
Antigen	LETMD1
Application	The suggested dilution range for the primary antibody in various assays is as follows: 1:500 to 1:2000 for Western Blotting, 1:50 to 1:200 for Immunohistochemistry, 1:100 to 1:500 for Immunofluorescence/Immunocytochemistry, and 1:20000 to 1:40000 for ELISA with peptide substrates. It is important to note that the optimal dilution may vary depending on the specific experimental conditions and the intended application. Therefore, it is advisable to perform a titration experiment to determine the ideal dilution for your specific experiment.
Immunogen	A synthesized peptide derived from human LETMD1.
MW	42kDa
Properties
Concentration	1mg/ml
purification	Through the use of SulfoLink™ Coupling Resin, the purification of the antiserum was accomplished via peptide affinity chromatography. It should be noted that the generated content has been rearranged to maintain a highly similar context to the original text.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 Â°C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 Â°C.Stable for 12 months from date of receipt.
Target
Background	Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.
Tissue specificity	Kidney, liver, skeletal muscle, heart and brain. Overexpressed in various tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon and uterine cervix.
Celluar localization	Mitochondrion;Nucleus;
UniPort	Q6P1Q0