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Rabbit Anti-SPINLW1 Polyclonal Antibody#abs136392

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Description

Catalog-specification	Delivery time	USD price
abs136392-100ug	1-2 Weeks	301.0
abs136392-50ug	1-2 Weeks	201.0

Overview
catalog	abs136392
Description	This particular gene, situated on chromosome 20q12-q13 among two clusters (centromeric and telomeric), encodes a protease inhibitor found in the epididymis. It comprises of both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Being a part of the telomeric cluster, it belongs to the WFDC gene family. The protein derived from this gene is capable of hindering human sperm motility, and variations in this gene have been linked to male infertility. Furthermore, a form of transcription known as read-through transcription occurs between this gene and the adjacent WFDC6 gene, which encodes the WAP four-disulfide core domain 6 protein. This information has been provided by RefSeq in November 2010. Please note that the generated content is based on the original text information but is presented in a rearranged format to ensure high similarity.
Other names	EPPIN, also known as Cancer/testis antigen 71 or CT71, is a protein encoded by the dJ461P17.2 gene. It is also referred to as Epididymal protease inhibitor or EPPIN1, EPPIN2, EPPIN3. Another name for EPPIN is Protease inhibitor WAP7 or Serine peptidase inhibitor like with Kunitz and WAP domains 1 (eppin). It is also known as SPINLW 1, WAP 7, WFDC 7, or WFDC7. Moreover, it is classified as a WAP four disulfide core domain protein 7 or WAP7. To create content based on the original information, one possible rearrangement could be: Eppin, also referred to as Cancer/testis antigen 71 or CT71, is a protein encoded by the dJ461P17.2 gene. It is classified as a serine peptidase inhibitor with Kunitz and WAP domains and is known by different names such as Epididymal protease inhibitor or EPPIN1, EPPIN2, EPPIN3. Additionally, it is identified as Protease inhibitor WAP7 or SPINLW 1. Furthermore, it is categorized under WFDC7 or WFDC 7 and is also recognized as WAP four disulfide core domain protein 7 or WAP7.
Source	Rabbit
Specificity	The endogenous levels of total SPINLW1 can be detected using the SPINLW1 Antibody. The generated content is derived from the original text information but is presented in a highly similar manner.
Species Reactivity	Human;Mouse;Rat
Antigen	SPINLW1
Application	: ，1:5001:2000。，1:501:200。，1:200001:40000。。
Immunogen	A synthesized peptide derived from human SPINLW1.
MW	15kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility.
Tissue specificity	In testis, expressed and secreted by Sertoli cells, appearing on the surface of testicular and ejaculate spermatozoa. Expressed in the spermatogonia and the earliest preleptotene spermatocytes. In the epididymis, is expressed and secreted by epithelial cells and covers the surface of epididymal spermatozoa and ciliated epithelial cells (at protein level). Expressed specifically in epididymis and testis. Isoform 2 is expressed only in the epididymis. Weak expression is detected in myoid cells as well as spermatogenic cells.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	O95925