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Rabbit Anti-IL26 Polyclonal Antibody#abs138503

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Description

Catalog-specification	Delivery time	USD price
abs138503-100ug	1-2 Weeks	301.0
abs138503-50ug	1-2 Weeks	201.0

Overview
catalog	abs138503
Other names	Interleukin 26, also known as IL-26 or AK155, is a protein that plays an important role in the immune system of humans. It is encoded by the IL26 gene and is primarily produced by the T-helper 17 (Th17) cells. IL-26 is known to stimulate the production of pro-inflammatory cytokines and chemokines, which help to recruit immune cells to the site of infection or injury. Additionally, it has been shown to induce the death of cancer cells in various types of tumors. IL26_HUMAN is the official symbol for interleukin 26 and is commonly studied for its potential therapeutic applications in diseases such as inflammation, autoimmune disorders, and cancer.
Source	Rabbit
Specificity	The ability of the IL26 Antibody to recognize endogenous levels of total IL26 has been demonstrated. Based on this information, it can be inferred that the IL26 Antibody is capable of specifically detecting the natural levels of IL26 within a biological sample.
Species Reactivity	Human
Antigen	IL26
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human IL26.
MW	20 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was accomplished through peptide affinity chromatography. The resulting product is highly refined and ready for use.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality, keep the store's temperature at -20 °C for a duration of one year. It is important to prevent the storage from experiencing repeated freeze and thaw cycles.
Storage buffer	The storage condition for Rabbit IgG is in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20 °C and can remain stable for 12 months from the date of receipt.
Target
Background	Having a potential role in the local mechanisms of mucosal immunity and displaying a proinflammatory function, this particular factor may play a significant part in inflammatory bowel disease. It effectively activates several signaling pathways, including STAT1, STAT3, MAPK1/3 (ERK1/2), JUN, and AKT. Notably, it induces the expression of SOCS3, TNF-alpha, and IL-8, while also leading to the secretion of IL-8 and IL-10 and the surface expression of ICAM1. Additionally, it has the capability to reduce the proliferation of intestinal epithelial cells. It is worth mentioning that its activity can be inhibited by heparin.
Tissue specificity	Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level).
Celluar localization	Cytosol;Extracellular region or secreted;
UniPort	Q9NPH9