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Rabbit Anti-RRAGA Polyclonal Antibody#abs137434

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Description

Catalog-specification	Delivery time	USD price
abs137434-100ug	1-2 Weeks	301.0
abs137434-50ug	1-2 Weeks	201.0

Overview
catalog	abs137434
Other names	One of the key proteins involved in adenovirus infection is Adenovirus E3 14.7 kDa-interacting protein 1, also known as FIP-1. This protein interacts with several other proteins in the host cell, including Rag A, or Ras-related GTP-binding protein A. The interaction between FIP-1 and Rag A helps the virus to evade the host immune system and establish an infection. Researchers are continuing to investigate the role of these proteins in adenovirus infection, with the goal of developing new therapies to combat this common viral illness.
Source	Rabbit
Specificity	The RRAGA Antibody is capable of detecting the total endogenous levels of RRAGA protein. To provide an alternative representation of the original text, one could say: The levels of total RRAGA protein can be effectively measured using the RRAGA Antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Zebrafish;Pig;Sheep;Rabbit;Bovine;Chicken
Antigen	RRAGA
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human RRAGA.
MW	37 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the preservation of the product for one year, store it at a temperature of -20 °C. It is important to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	The formulation of the Rabbit IgG is in a solution of phosphate buffered saline, with pH 7.4, containing 150 millimolar NaCl, 0.02% sodium azide, and 50% glycerol. It is advised to store the solution at a temperature of -20 Celsius. The solution should remain stable for up to one year from the date of reception. It is recommended to handle the solution with care and to follow appropriate safety protocols when dealing with it.
Target
Background	Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.
Tissue specificity	Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
Posttranslational modification	Ubiquitinated. 'Lys-68'-linked polyubiquitination of the GDP-bound inactive form of RRAGA by RNF152 is increased in response to amino acid starvation. Polyubiquitination promotes interaction with the GATOR1 complex. This does not affect RRAGA degradation.
Celluar localization	Cytosol;Endosome;Lysosome;Nucleus;
UniPort	Q7L523