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Rabbit Anti-IL21 Polyclonal Antibody#abs135120

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Description

Catalog-specification	Delivery time	USD price
abs135120-100ug	1-2 Weeks	301.0
abs135120-50ug	1-2 Weeks	201.0

Overview
catalog	abs135120
Other names	Interleukin 21, also known as IL-21 or IL21, is a protein that plays an important role in the immune system. CVID11 is a rare condition where individuals have a reduced ability to produce antibodies, and IL-21 has been shown to be involved in the development and differentiation of B cells, which produce antibodies. IL-21 is also involved in the activation of T cells, which are important for fighting infections. Overall, IL-21 is a critical cytokine in the immune response and has potential as a therapeutic target for a variety of diseases.
Source	Rabbit
Specificity	Detecting endogenous levels of total IL21 is possible using the IL21 Antibody. We can rely on this antibody to accurately measure the IL21 levels present in the organism. Through its specificity, the IL21 Antibody ensures the detection of the complete IL21 protein, enabling researchers to gather valuable information about its expression. This antibody opens doors for studying the biological relevance and behavior of IL21 within the organism.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Sheep;Bovine;Horse;Pig;
Antigen	IL21
Application	For Western blot analysis, a dilution ratio of 1:500 to 1:1000 is recommended. Immunofluorescence or Immunocytochemistry assays require a dilution of 1:100 to 1:500. For ELISA using a peptide substrate, a dilution of 1:20000 to 1:40000 is recommended. It is essential to follow these instructions carefully to obtain accurate and reliable results in your experiments.
Immunogen	A synthesized peptide.
MW	18 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. To obtain a highly purified solution, this process was crucial for removing impurities and isolating the desired peptide.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is advisable to store it at a temperature of -20 °C for a period of one year. It is crucial to avoid exposing the product to repeated cycles of freezing and thawing as this can have a negative impact on its efficacy. Therefore, it is recommended that adequate measures are taken to ensure the appropriate storage conditions are maintained throughout the product's shelf life.
Storage buffer	The Rabbit IgG solution comes in a formulation of phosphate buffered saline at pH 7.4, containing 150mM of NaCl and 0.02% sodium azide. Additionally, it contains 50% glycerol and must be stored at a temperature of -20°C. This solution is stable for up to 12 months from the date of receipt.
Target
Background	Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Tissue specificity	Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.
Celluar localization	Extracellular region or secreted;
UniPort	Q9HBE4