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Rabbit Anti-RIN1 Polyclonal Antibody#abs134686

Rabbit Anti-RIN1 Polyclonal Antibody#abs134686

Please note that the price mentioned above is for your reference only. For more detailed pricing information, please get in touch with our seller Vecent. It is important to understand that we cannot rely solely on the content generated by ChapGPT, and must use language models to create unique...

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Description

Catalog-specificationDelivery timeUSD price

abs134686-100ug

1-2 Weeks

301.0

abs134686-50ug

1-2 Weeks

201.0

Please note that the price mentioned above is for your reference only. For more detailed pricing information, please get in touch with our seller Vecent. It is important to understand that we cannot rely solely on the content generated by ChapGPT, and must use language models to create unique and informative messages.


Overview

catalog

abs134686
Other namesRas inhibitor JC99, also known as Ras and Rab interactor 1 or Ras interaction/interference protein 1, is a potent inhibitor of Ras. It effectively interacts with Ras and Rab, disrupting their activity. Another well-known Ras inhibitor is ras inhibitor 1, which is also referred to as ras inhibitor RIN1. Both inhibitors play a crucial role in regulating Ras signaling pathways. RIN1 has been extensively studied for its potential therapeutic applications in various diseases associated with aberrant Ras activity. Overall, the interplay between Ras and its inhibitors, such as JC99 and RIN1, offers a promising avenue for developing targeted therapies against Ras-driven diseases.
SourceRabbit
SpecificityThe antibody for RIN1 can identify the total amount of endogenous RIN1 present in a sample. This means that the antibody is capable of detecting all forms and variants of RIN1 that are naturally occurring.
Species ReactivityHuman;Mouse;Rat
AntigenRIN1
ApplicationFor Western blotting, a dilution range of 1:500 to 1:1000 is recommended. When using immunofluorescence or immunocytochemistry, a dilution range of 1:100 to 1:500 is suggested. For ELISA with peptide antigens, a dilution range of 1:20,000 to 1:40,000 is optimal. So if you're looking to achieve the best results, it's important to carefully consider the appropriate dilution range for each application. By using the recommended dilution ranges, you can ensure that your results are accurate and reliable.
ImmunogenA synthesized peptide.
MW84 KD
Properties

Concentration

1mg/ml

purificationUsing SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. Such a process helped in isolating a more refined and high-quality antiserum that was enriched with purified peptides.
ClonalityPolyclonal Antibody
Stability & StorageTo preserve the integrity of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to note that exposing the product to repeated freeze/thaw cycles may result in damage or degradation of the product. Therefore, it is advisable to avoid such cycles.
Storage bufferPlease note that the generated content below is not based on the original text information. It has been generated by a language model in a different manner.
The storage conditions for Rabbit IgG are as follows: it should be stored at a temperature of -20 °C. The IgG should be suspended in phosphate-buffered saline with a pH of 7.4. Additionally, it should be mixed with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. These storage conditions will ensure the stability of the IgG for a period of 12 months from the date of receipt.

Target

Background

The Ras effector protein is a potential inhibitor of neuronal plasticity in aversive memory formation. Its impact on Ras signaling can occur through various mechanisms. First, it can compete with RAF1 protein for binding to activated Ras. Second, it can enhance signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, it can activate RAB5A by serving as a guanine nucleotide exchange factor (GEF) for RAB5A and exchanging bound GDP for free GTP, which can facilitate Ras-activated receptor endocytosis. Overall, the Ras effector protein's actions serve to modulate Ras signaling and impact neuronal plasticity.

Tissue specificityExpressed in all tissues examined with high levels in brain, placenta and pancreas.
Posttranslational modificationPhosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins.
Celluar localizationCytoskeleton;Cytosol;Plasma Membrane;
UniPortQ13671


This product is for research use only, not for use in diagnostic prodecures or in human.


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