Rabbit Anti-RAP1GAP Polyclonal Antibody#abs134685
Please note that the mentioned price is only for your reference. If you require more detailed pricing information, we recommend reaching out to our sales representative, Vecent. They will provide you with accurate pricing details and assist you with any queries you may have. This product is for...
Description
| Catalog-specification | Delivery time | USD price |
abs134685-100ug | 1-2 Weeks | 301.0 |
abs134685-50ug | 1-2 Weeks | 201.0 |
Please note that the mentioned price is only for your reference. If you require more detailed pricing information, we recommend reaching out to our sales representative, Vecent. They will provide you with accurate pricing details and assist you with any queries you may have.
| Overview | |
catalog | abs134685 |
| Other names | KIAA0474, also known as Rap1 GTPase activating protein 1 or RAP1GA1, is a protein involved in the regulation of Rap1 GTPase activity. Its primary function is to act as a GTPase-activating protein for Rap1, a small G protein that plays a critical role in cell adhesion, migration, and proliferation. Rap1 GTPase activating protein 1, encoded by the gene Rap1ga1, is responsible for catalyzing the hydrolysis of GTP bound to Rap1, thus inactivating Rap1 and terminating downstream signaling pathways. This regulatory mechanism ensures proper control and coordination of cellular processes. With its distinct domain structure and conserved catalytic domain, Rap1GAP exhibits specificity towards Rap1. By promoting Rap1 GTP hydrolysis, Rap1GAP serves as a negative regulator, dampening Rap1-mediated signaling events. The importance of Rap1GAP in cellular processes is underscored by its involvement in various biological functions, including embryonic development, vascular homeostasis, and immune response. Dysregulation or dysfunction of Rap1GAP has also been associated with the development and progression of diseases, such as cancer and cardiovascular disorders. In conclusion, Rap1GAP, also known as RAP1GA1 or KIAA0474, is a critical modulator of Rap1 GTPase activity, regulating important cellular processes. Further research on the molecular mechanisms and physiological importance of Rap1GAP is necessary to deepen our understanding of its role in health and disease. |
| Source | Rabbit |
| Specificity | The total amount of RAP1GAP present naturally in a sample can be detected using the RAP1GAP Antibody. The antigen recognized by this antibody is endogenous, indicating that it is present within the sample without being introduced from an external source. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Xenopus;Zebrafish;Pig;Sheep;Horse;Bovine; |
| Antigen | RAP1GAP |
| Application | WB: The dilution range for Western Blot (WB) is typically 1:500 to 1:1000. This means that the primary antibody should be diluted at a ratio of 1 part antibody to 500-1000 parts diluent. IHC: For Immunohistochemistry (IHC), the recommended dilution range for the primary antibody is usually 1:50 to 1:200. This means that the antibody should be diluted at a ratio of 1 part antibody to 50-200 parts diluent. IF/ICC: In the case of Immunofluorescence (IF) or Immunocytochemistry (ICC), the optimal dilution range for the primary antibody is typically 1:100 to 1:500. This means that the antibody should be diluted at a ratio of 1 part antibody to 100-500 parts diluent. ELISA(peptide): For ELISA using peptide antigens, the suggested dilution range for the primary antibody is usually 1:20000 to 1:40000. This means that the antibody should be diluted at a ratio of 1 part antibody to 20000-40000 parts diluent. |
| Immunogen | A synthesized peptide. |
| MW | 73 KD |
| Properties | |
Concentration | 1mg/ml |
| purification | By utilizing SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography for purification. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | One year storage is recommended at -20 °C to maintain the product's quality. It is important to avoid subjecting the product to repeated freeze/thaw cycles. |
| Storage buffer | This rabbit IgG comes in a phosphate buffered saline solution with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% glycerol as a stabilizing agent. To maintain its quality, store this product at -20 °C and it will remain stable for up to 12 months from the date of receipt. |
Target | |
Background | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. |
| Tissue specificity | Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues. |
| Celluar localization | Cytosol;Golgi apparatus; |
| UniPort | P47736 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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