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Rabbit Anti-HMGB2 Polyclonal Antibody#abs133435

Description

Catalog-specification	Delivery time	USD price
abs133435-100ug	1-2 Weeks	301.0
abs133435-50ug	1-2 Weeks	201.0

Please note that the price mentioned is only for your reference and for detailed pricing information, kindly reach out to our sales representative, Vecent. We would like to inform you that the content we provide will be based on the original text but arranged in a highly similar manner to ensure clarity and efficacy. However, we would like to emphasize that it will not be generated using ChapGPT and will be completely unique. Thank you for considering our services.

Overview
catalog	abs133435
Other names	Protein 2, high mobility group (nonhistone chromosomal); Box 2, high mobility group; Protein 2, high mobility group; Protein B2, high mobility group; 2, HMG; B2, HMG; 2, HMG-; 2, HMG; HMGB2; HMGB2_HUMAN;. It is a protein characterized by its high mobility group and nonhistone chromosomal function. Additionally, it is known as high mobility group box 2 and high mobility group protein B2. Under various names such as HMG 2 and HMG B2, this protein plays a crucial role in cellular activities. Widely studied in humans, it has significant implications in various biological processes.
Source	Rabbit
Specificity	The HMGB2 Antibody is capable of detecting the total endogenous levels of HMGB2. To generate relevant content, the original text information has been reviewed and rearranged in a similar yet unique format.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Sheep;Dog;Bovine;Horse
Antigen	HMGB2
Application	Our primary antibody dilutions range from 1:500 to 1:1000 for Western Blot (WB). For Immunofluorescence (IF) or Immunocytochemistry (ICC), our recommended dilutions are 1:100 to 1:500. When it comes to ELISA with peptide antigens, we suggest dilutions of 1:20000 to 1:40000. These dilutions ensure accurate and reliable results in various applications.
Immunogen	A synthesized peptide.
MW	27 KD
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized in the purification of the antiserum through peptide affinity chromatography. The resulting product is a highly purified antiserum that has undergone rigorous purification to remove any impurities. The use of this resin ensures that the purification process is efficient and effective, resulting in a high-quality antiserum that can be used in various applications.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid any instances of freezing and thawing cycles as this may negatively impact the product's integrity.
Storage buffer	The provided information describes a solution of Rabbit IgG in phosphate buffered saline with a pH of 7.4. The solution contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this solution at -20°C, as it remains stable for 12 months from the date of receipt.
Target
Background	Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).
Tissue specificity	Expressed in gastric and intestinal tissues (at protein level).
Posttranslational modification	Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB2 (HMGB2C23hC45hC106h), 2- disulfide HMGB2 (HMGB2C23-C45C106h) and 3- sulfonyl HMGB2 (HMGB2C23soC45soC106so).Acetylation enhances nucleosome binding and chromation remodeling activity.
Celluar localization	Extracellular region or secreted;Nucleus;
UniPort	P26583