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Rabbit Anti-SOCS2 Polyclonal Antibody#abs137610

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Description

Catalog-specification	Delivery time	USD price
abs137610-100ug	1-2 Weeks	301.0
abs137610-50ug	1-2 Weeks	201.0

Overview
catalog	abs137610
Other names	CIS 2, also known as Cish 2 or Cytokine-inducible SH2 protein 2, is a protein that belongs to the SOCS family. Its official name is Suppressor of cytokine signaling 2. Other names include SSI 2, SSI2, STAT induced STAT inhibitor 2, and STATI 2. CIS 2 is a cytokine-inducible SH2 protein that functions as a negative regulator of cytokine signaling pathways. It has been shown to inhibit JAK-STAT and MAPK signaling pathways by binding to the activated cytokine receptors and modulating downstream signaling events. CIS 2 is expressed in a wide range of tissues and plays an important role in maintaining immune homeostasis. Its dysregulation has been linked to various diseases, including inflammation, autoimmunity, and cancer. Understanding the molecular mechanisms underlying CIS 2 function will provide insights into the pathogenesis of these diseases and may lead to the development of novel therapeutic interventions.
Source	Rabbit
Specificity	The detection of endogenous levels of total SOCS2 is achieved using the SOCS2 Antibody. To create a highly similar content by rearranging the information given above, one can rephrase it as follows: The total SOCS2 present in the organism can be effectively identified by utilizing the SOCS2 Antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine
Antigen	SOCS2
Application	(WB)1:1000-3000，/(IF/ICC)1:200-1:500，(ELISA，)1:20000-1:40000。，。
Immunogen	A synthesized peptide derived from human SOCS2.
MW	23 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Please ensure that the product is stored at a temperature of -20 °C for a duration of one year. It is crucial to avoid subjecting the product to repeated freeze/thaw cycles during this time.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it should be stored at -20 °C in phosphate buffered saline with a pH of 7.4. The solution should contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This formulation ensures the stability of the antibody for a period of 12 months from the date of receipt. It is important to adhere to these storage conditions to maintain the integrity and functionality of the Rabbit IgG.
Target
Background	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Tissue specificity	High expression in heart, placenta, lung, kidney and prostate.
Celluar localization	Cytosol;
UniPort	O14508