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Rabbit Anti-GTF3A Polyclonal Antibody#abs134876

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Description

Catalog-specification	Delivery time	USD price
abs134876-100ug	1-2 Weeks	301.0
abs134876-50ug	1-2 Weeks	201.0

Overview
catalog	abs134876
Other names	General transcription factor 3A, also known as TFIIIA or GTF3A, is a crucial player in the process of transcription initiation in eukaryotic cells. It belongs to the family of general transcription factors and is responsible for the recruitment of RNA polymerase III to the promoter region of target genes. AP2 and Factor A are other names for this protein. TFIIIA is a multi-domain protein with three zinc-finger motifs that bind specifically to the internal control sequence of the genes it regulates. Its presence is necessary for the proper expression of small RNA genes, including 5S rRNA, transfer RNA, and other non-coding RNAs. The human TF3A_HUMAN gene encodes for the GTF3A protein, and mutations in this gene have been associated with rare genetic disorders like Lethal Congenital Contracture Syndrome, type 2C. Further research on TFIIIA and its interactions can have significant implications for understanding transcription regulation and its role in disease.
Source	Rabbit
Specificity	The antibody called GTF3A Antibody is capable of identifying total GTF3A protein levels present within an organism's system. This antibody acknowledges the endogenous form of the protein during testing and analysis.
Species Reactivity	Human
Antigen	GTF3A
Application	1:500~1:1000，/1:100-1:500，（ELISA）1:20000-1:40000。，。
Immunogen	A synthesized peptide.
MW	41 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was efficiently purified through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to keep the item at a temperature of -20°C for a period of one year. It is important to avoid exposing it to repeated cycles of freezing and thawing in order to maintain its quality and efficacy over time. By adhering to these guidelines, you can help to ensure that the item remains viable and effective for its intended purpose for as long as possible.
Storage buffer	The Rabbit IgG comes in a solution that is pH 7.4 and contains phosphate buffered saline, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at a temperature of -20 °C, and it remains stable for up to 12 months from the date of receipt.
Target
Background	Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity).
Tissue specificity	Ubiquitous.
Celluar localization	Nucleus;
UniPort	Q92664

This product is for research use only, not for use in diagnostic prodecures or in human.

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